Methylmalonic acid promotes colorectal cancer progression via activation of Wnt/β-catenin pathway mediated epithelial–mesenchymal transition

Methylmalonic acid promotes colorectal cancer progression via activation of Wnt/β-catenin pathway mediated epithelial–mesenchymal transition

Abstract Background It has been manifested in several studies that age-related metabolic reprogramming is associated with tumor progression, in particular, colorectal cancer (CRC). Here we investigated the role of upregulated metabolites of the aged serum, including methylmalonic acid (MMA), phospho...

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Bibliographic Details
Main Authors: Chunhua Hu, Mujie Ye, Jianan Bai, Pengfei Liu, Feiyu Lu, Jinhao Chen, Ping Yu, Tiaotiao Chen, Xiaoting Shi, Qiyun Tang
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Cancer Cell International
Subjects:
Colorectal cancer
Age
Methylmalonic acid
Epithelial–mesenchymal transition
Wnt
β-catenin
Online Access:https://doi.org/10.1186/s12935-023-02973-z

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