Plasmacytoid urothelial carcinoma of the bladder
Plasmacytoid urothelial carcinoma (PUC) of the urinary bladder is an uncommon and aggressive variant of urothelial carcinoma associated with late presentation and poor prognosis. Immunohistochemical examination showing expression of epithelial markers, CD138, and losing the membranous expression of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2014;volume=57;issue=2;spage=320;epage=322;aulast=Qin |
| _version_ | 1819083040933019648 |
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| author | Meihua Qin Gangping Wang Yanqing Sun Qun He |
| author_facet | Meihua Qin Gangping Wang Yanqing Sun Qun He |
| author_sort | Meihua Qin |
| collection | DOAJ |
| description | Plasmacytoid urothelial carcinoma (PUC) of the urinary bladder is an uncommon and aggressive variant of urothelial carcinoma associated with late presentation and poor prognosis. Immunohistochemical examination showing expression of epithelial markers, CD138, and losing the membranous expression of E-cadherin confirms evidence of PUC. Here, we report a case of bladder PUC of a 74-year-old male who presented with hematuria. A transurethral biopsy revealed urothelial carcinoma with plasmacytoid appearance. The diagnostic dilemmas of this unusual variant of urothelial malignancy and its clinical impact are discussed. The pathological diagnosis was PUC (High-grade, pT4N2M0) with diffuse muscle, small tracts, and vascular invasion, in which almost of the areas studied on the tissue section showed Plasmacytoid differentiation. |
| first_indexed | 2024-12-21T20:26:15Z |
| format | Article |
| id | doaj.art-4a8889024bb34868a5762800176df908 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-21T20:26:15Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-4a8889024bb34868a5762800176df9082022-12-21T18:51:22ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292014-01-0157232032210.4103/0377-4929.134730Plasmacytoid urothelial carcinoma of the bladderMeihua QinGangping WangYanqing SunQun HePlasmacytoid urothelial carcinoma (PUC) of the urinary bladder is an uncommon and aggressive variant of urothelial carcinoma associated with late presentation and poor prognosis. Immunohistochemical examination showing expression of epithelial markers, CD138, and losing the membranous expression of E-cadherin confirms evidence of PUC. Here, we report a case of bladder PUC of a 74-year-old male who presented with hematuria. A transurethral biopsy revealed urothelial carcinoma with plasmacytoid appearance. The diagnostic dilemmas of this unusual variant of urothelial malignancy and its clinical impact are discussed. The pathological diagnosis was PUC (High-grade, pT4N2M0) with diffuse muscle, small tracts, and vascular invasion, in which almost of the areas studied on the tissue section showed Plasmacytoid differentiation.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2014;volume=57;issue=2;spage=320;epage=322;aulast=QinCD138E-cadherinplasmacytoidurothelial carcinoma |
| spellingShingle | Meihua Qin Gangping Wang Yanqing Sun Qun He Plasmacytoid urothelial carcinoma of the bladder Indian Journal of Pathology and Microbiology CD138 E-cadherin plasmacytoid urothelial carcinoma |
| title | Plasmacytoid urothelial carcinoma of the bladder |
| title_full | Plasmacytoid urothelial carcinoma of the bladder |
| title_fullStr | Plasmacytoid urothelial carcinoma of the bladder |
| title_full_unstemmed | Plasmacytoid urothelial carcinoma of the bladder |
| title_short | Plasmacytoid urothelial carcinoma of the bladder |
| title_sort | plasmacytoid urothelial carcinoma of the bladder |
| topic | CD138 E-cadherin plasmacytoid urothelial carcinoma |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2014;volume=57;issue=2;spage=320;epage=322;aulast=Qin |
| work_keys_str_mv | AT meihuaqin plasmacytoidurothelialcarcinomaofthebladder AT gangpingwang plasmacytoidurothelialcarcinomaofthebladder AT yanqingsun plasmacytoidurothelialcarcinomaofthebladder AT qunhe plasmacytoidurothelialcarcinomaofthebladder |