A Comprehensive Review of Bioactive Peptides from Marine Fungi and Their Biological Significance
Fungal marine microorganisms are a valuable source of bioactive natural products. Fungal secondary metabolites mainly comprise alkaloids, terpenoids, peptides, polyketides, steroids, and lactones. Proteins and peptides from marine fungi show minimal human toxicity and less adverse effects comparable...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/17/10/559 |
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| author | Fadia S. Youssef Mohamed L. Ashour Abdel Nasser B. Singab Michael Wink |
| author_facet | Fadia S. Youssef Mohamed L. Ashour Abdel Nasser B. Singab Michael Wink |
| author_sort | Fadia S. Youssef |
| collection | DOAJ |
| description | Fungal marine microorganisms are a valuable source of bioactive natural products. Fungal secondary metabolites mainly comprise alkaloids, terpenoids, peptides, polyketides, steroids, and lactones. Proteins and peptides from marine fungi show minimal human toxicity and less adverse effects comparable to synthetic drugs. This review summarizes the chemistry and the biological activities of peptides that were isolated and structurally elucidated from marine fungi. Relevant fungal genera including <i>Acremonium</i>, <i>Ascotricha</i>, <i>Aspergillus</i>, <i>Asteromyces</i>, <i>Ceratodictyon</i>, <i>Clonostachys</i>, <i>Emericella</i>, <i>Exserohilum</i>, <i>Microsporum</i>, <i>Metarrhizium</i>, <i>Penicillium</i>, <i>Scytalidium</i>, <i>Simplicillium</i>, <i>Stachylidium</i>, <i>Talaromyces</i>, <i>Trichoderma</i>, as well as <i>Zygosporium</i> were extensively reviewed. About 131 peptides were reported from these 17 genera and their structures were unambiguously determined using 1D and 2D NMR (one and two dimensional nuclear magnetic resonance) techniques in addition to HRMS (high resolution mass spectrometry). Marfey and Mosher reactions were used to confirm the identity of these compounds. About 53% of the isolated peptides exhibited cytotoxic, antimicrobial, and antiviral activity, meanwhile, few of them showed antidiabetic, lipid lowering, and anti-inflammatory activity. However 47% of the isolated peptides showed no activity with respect to the examined biological activity and thus required further in depth biological assessment. In conclusion, when searching for bioactive natural products, it is worth exploring more peptides of fungal origin and assessing their biological activities. |
| first_indexed | 2024-04-11T22:31:55Z |
| format | Article |
| id | doaj.art-4a88cc3b7f0a4eb39d648f4208c9481e |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T22:31:55Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-4a88cc3b7f0a4eb39d648f4208c9481e2022-12-22T03:59:20ZengMDPI AGMarine Drugs1660-33972019-09-01171055910.3390/md17100559md17100559A Comprehensive Review of Bioactive Peptides from Marine Fungi and Their Biological SignificanceFadia S. Youssef0Mohamed L. Ashour1Abdel Nasser B. Singab2Michael Wink3Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo 11566, EgyptDepartment of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo 11566, EgyptDepartment of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo 11566, EgyptInstitute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, GermanyFungal marine microorganisms are a valuable source of bioactive natural products. Fungal secondary metabolites mainly comprise alkaloids, terpenoids, peptides, polyketides, steroids, and lactones. Proteins and peptides from marine fungi show minimal human toxicity and less adverse effects comparable to synthetic drugs. This review summarizes the chemistry and the biological activities of peptides that were isolated and structurally elucidated from marine fungi. Relevant fungal genera including <i>Acremonium</i>, <i>Ascotricha</i>, <i>Aspergillus</i>, <i>Asteromyces</i>, <i>Ceratodictyon</i>, <i>Clonostachys</i>, <i>Emericella</i>, <i>Exserohilum</i>, <i>Microsporum</i>, <i>Metarrhizium</i>, <i>Penicillium</i>, <i>Scytalidium</i>, <i>Simplicillium</i>, <i>Stachylidium</i>, <i>Talaromyces</i>, <i>Trichoderma</i>, as well as <i>Zygosporium</i> were extensively reviewed. About 131 peptides were reported from these 17 genera and their structures were unambiguously determined using 1D and 2D NMR (one and two dimensional nuclear magnetic resonance) techniques in addition to HRMS (high resolution mass spectrometry). Marfey and Mosher reactions were used to confirm the identity of these compounds. About 53% of the isolated peptides exhibited cytotoxic, antimicrobial, and antiviral activity, meanwhile, few of them showed antidiabetic, lipid lowering, and anti-inflammatory activity. However 47% of the isolated peptides showed no activity with respect to the examined biological activity and thus required further in depth biological assessment. In conclusion, when searching for bioactive natural products, it is worth exploring more peptides of fungal origin and assessing their biological activities.https://www.mdpi.com/1660-3397/17/10/559biological activitychemistrymarine derived fungipeptides |
| spellingShingle | Fadia S. Youssef Mohamed L. Ashour Abdel Nasser B. Singab Michael Wink A Comprehensive Review of Bioactive Peptides from Marine Fungi and Their Biological Significance Marine Drugs biological activity chemistry marine derived fungi peptides |
| title | A Comprehensive Review of Bioactive Peptides from Marine Fungi and Their Biological Significance |
| title_full | A Comprehensive Review of Bioactive Peptides from Marine Fungi and Their Biological Significance |
| title_fullStr | A Comprehensive Review of Bioactive Peptides from Marine Fungi and Their Biological Significance |
| title_full_unstemmed | A Comprehensive Review of Bioactive Peptides from Marine Fungi and Their Biological Significance |
| title_short | A Comprehensive Review of Bioactive Peptides from Marine Fungi and Their Biological Significance |
| title_sort | comprehensive review of bioactive peptides from marine fungi and their biological significance |
| topic | biological activity chemistry marine derived fungi peptides |
| url | https://www.mdpi.com/1660-3397/17/10/559 |
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