Six week evaluation of the potential for topical desoximetasone 0.25% spray to induce photoallergic skin reaction
Purpose: Desoximetasone 0.25% topical spray is a novel formulation that has not been tested or approved for safety and efficacy. The primary objective was to determine the potential of desoximetasone 0.25 and 0.05% topical sprays, as well as a vehicle to induce photoallergic skin reaction after repe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-04-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2017.1395803 |
| _version_ | 1797683734732865536 |
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| author | Nupur U. Patel Asha Gowda Alexandra Grammenos Omobola Onikoyi Steven R. Feldman |
| author_facet | Nupur U. Patel Asha Gowda Alexandra Grammenos Omobola Onikoyi Steven R. Feldman |
| author_sort | Nupur U. Patel |
| collection | DOAJ |
| description | Purpose: Desoximetasone 0.25% topical spray is a novel formulation that has not been tested or approved for safety and efficacy. The primary objective was to determine the potential of desoximetasone 0.25 and 0.05% topical sprays, as well as a vehicle to induce photoallergic skin reaction after repeated topical application and irradiation to the skin using a controlled photopatch testing procedure. Materials and methods: 53 subjects completed the study, each with six application sites (two of each treatment), three of which were irradiated and three non-irradiated, for an induction period of three weeks and then challenge period at week 6. Results: Desoximetasone 0.25 and 0.05%, as well as vehicle showed no evidence of potential to induce photosensitization. There was statistically significantly greater irritation at the vehicle irradiated site in comparison to the irradiated treatment area of desoximetasone 0.25% (p = .005) and the irradiated treatment area of desoximetasone 0.05% (p = .008). Conclusion: Our results suggest that regular treatment with desoximetasone 0.25 and 0.05% spray, followed by UV light exposure does not induce photosensitization or photo-irritation. These findings increase confidence for the use of this topical spray in eczema or psoriasis patients who may also be receiving UV light therapy and may contribute to the clinical management of these patients. |
| first_indexed | 2024-03-12T00:19:04Z |
| format | Article |
| id | doaj.art-4a88d5a008e04fb98629c2ebbd58fbcf |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:19:04Z |
| publishDate | 2018-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-4a88d5a008e04fb98629c2ebbd58fbcf2023-09-15T14:08:31ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532018-04-0129326927110.1080/09546634.2017.13958031395803Six week evaluation of the potential for topical desoximetasone 0.25% spray to induce photoallergic skin reactionNupur U. Patel0Asha Gowda1Alexandra Grammenos2Omobola Onikoyi3Steven R. Feldman4Wake Forest University School of MedicineWake Forest University School of MedicineWake Forest University School of MedicineWake Forest University School of MedicineWake Forest University School of MedicinePurpose: Desoximetasone 0.25% topical spray is a novel formulation that has not been tested or approved for safety and efficacy. The primary objective was to determine the potential of desoximetasone 0.25 and 0.05% topical sprays, as well as a vehicle to induce photoallergic skin reaction after repeated topical application and irradiation to the skin using a controlled photopatch testing procedure. Materials and methods: 53 subjects completed the study, each with six application sites (two of each treatment), three of which were irradiated and three non-irradiated, for an induction period of three weeks and then challenge period at week 6. Results: Desoximetasone 0.25 and 0.05%, as well as vehicle showed no evidence of potential to induce photosensitization. There was statistically significantly greater irritation at the vehicle irradiated site in comparison to the irradiated treatment area of desoximetasone 0.25% (p = .005) and the irradiated treatment area of desoximetasone 0.05% (p = .008). Conclusion: Our results suggest that regular treatment with desoximetasone 0.25 and 0.05% spray, followed by UV light exposure does not induce photosensitization or photo-irritation. These findings increase confidence for the use of this topical spray in eczema or psoriasis patients who may also be receiving UV light therapy and may contribute to the clinical management of these patients.http://dx.doi.org/10.1080/09546634.2017.1395803desoximetasonetopical;corticosteroidslight-exposureirritation potential |
| spellingShingle | Nupur U. Patel Asha Gowda Alexandra Grammenos Omobola Onikoyi Steven R. Feldman Six week evaluation of the potential for topical desoximetasone 0.25% spray to induce photoallergic skin reaction Journal of Dermatological Treatment desoximetasone topical;corticosteroids light-exposure irritation potential |
| title | Six week evaluation of the potential for topical desoximetasone 0.25% spray to induce photoallergic skin reaction |
| title_full | Six week evaluation of the potential for topical desoximetasone 0.25% spray to induce photoallergic skin reaction |
| title_fullStr | Six week evaluation of the potential for topical desoximetasone 0.25% spray to induce photoallergic skin reaction |
| title_full_unstemmed | Six week evaluation of the potential for topical desoximetasone 0.25% spray to induce photoallergic skin reaction |
| title_short | Six week evaluation of the potential for topical desoximetasone 0.25% spray to induce photoallergic skin reaction |
| title_sort | six week evaluation of the potential for topical desoximetasone 0 25 spray to induce photoallergic skin reaction |
| topic | desoximetasone topical;corticosteroids light-exposure irritation potential |
| url | http://dx.doi.org/10.1080/09546634.2017.1395803 |
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