Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: a systematic review with meta-analysis
Abstract Background Pro-inflammatory cytokines expressed in human immune deficiency virus (HIV) infection, may induce oxidative stress likely to compromise the patency of the airways or damage the lung tissues/cardiac function. However, physical (aerobic and/or resistance) exercise-induced release o...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-04-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-019-3960-0 |
| _version_ | 1828518339679354880 |
|---|---|
| author | S. C. Ibeneme C. Omeje H. Myezwa Salome Nwaelom Ezeofor E. M. Anieto F. Irem Amaka Obiageli Nnamani Fortune Elochukwu Ezenwankwo G. C. Ibeneme |
| author_facet | S. C. Ibeneme C. Omeje H. Myezwa Salome Nwaelom Ezeofor E. M. Anieto F. Irem Amaka Obiageli Nnamani Fortune Elochukwu Ezenwankwo G. C. Ibeneme |
| author_sort | S. C. Ibeneme |
| collection | DOAJ |
| description | Abstract Background Pro-inflammatory cytokines expressed in human immune deficiency virus (HIV) infection, may induce oxidative stress likely to compromise the patency of the airways or damage the lung tissues/cardiac function. However, physical (aerobic and/or resistance) exercise-induced release of heat shock protein, immune function alteration or reduced tissue hypoxia, have been highlighted as possible mechanisms by which increasing physical activity may reduce plasma pro-inflammatory cytokines in uninfected individuals and should be appraised in the literature for evidence of similar benefits in people living with HIV (PLWH). Therefore, we evaluated the effects of physical exercises on 1) inflammatory biomarkers and 2) cardiopulmonary function (VO2 Max) in PLWH. Method A systematic review was conducted using the Cochrane Collaboration protocol. Searching databases, up to January 2018. Only randomized control trials investigating the effects of either aerobic or resistance or a combination of both exercise types with a control/other intervention(s) for a period of at least 4 weeks among adults living with HIV, were included. Two independent reviewers determined the eligibility of the studies. Data were extracted and risk of bias (ROB) was assessed with the Cochrane Collaboration ROB tool. Meta-analyses were conducted with random effect models using the Review Manager (RevMan) computer software. Result Twenty-three studies met inclusion criteria (n = 1073 participants at study completion) comprising male and female with age range 18–65 years. Three meta-analyses across three sub-groups comparisons were performed. The result showed no significant change in biomarkers of inflammation (IL-6 and IL-1β) unlike a significant (Z = 3.80, p < 0.0001) improvement in VO2 Max. Overall, the GRADE evidence for this review was of moderate quality. Conclusion There was evidence that engaging in either aerobic or resistance exercise, or a combination of both exercises, two to five times per week can lead to a significant improvement in cardiopulmonary function but not biomarkers of inflammation (IL-6 and IL-1β). However, this should not be interpreted as “No evidence of effect” because the individual trial studies did not attain sufficient power to detect treatment effects. The moderate grade evidence for this review suggests that further research may likely have an important impact on our confidence in the estimate of effects and may change the estimate. |
| first_indexed | 2024-12-11T18:53:59Z |
| format | Article |
| id | doaj.art-4a88ed6bf6e7424285fb1dec27299c66 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-11T18:53:59Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-4a88ed6bf6e7424285fb1dec27299c662022-12-22T00:54:12ZengBMCBMC Infectious Diseases1471-23342019-04-0119112210.1186/s12879-019-3960-0Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: a systematic review with meta-analysisS. C. Ibeneme0C. Omeje1H. Myezwa2Salome Nwaelom Ezeofor3E. M. Anieto4F. Irem5Amaka Obiageli Nnamani6Fortune Elochukwu Ezenwankwo7G. C. Ibeneme8Department of Medical Rehabilitation, Faculty of Health Sciences, University of NigeriaDepartment of Medical Rehabilitation, Faculty of Health Sciences, University of NigeriaDepartment of Physiotherapy, Faculty of Health Sciences, School of Therapeutic Studies, University of the WitwatersrandDepartment of Radiation Medicine, Faculty of Medical Sciences, College of Medicine, University of NigeriaDepartment of Medical Rehabilitation, Faculty of Health Sciences, University of NigeriaDepartment of Medical Rehabilitation, Faculty of Health Sciences, University of NigeriaDepartment of Radiation Medicine, Faculty of Medical Sciences, College of Medicine, University of NigeriaDepartment of Medical Rehabilitation, Faculty of Health Sciences, University of NigeriaDepartment of Nursing Sciences, Ebonyi State UniversityAbstract Background Pro-inflammatory cytokines expressed in human immune deficiency virus (HIV) infection, may induce oxidative stress likely to compromise the patency of the airways or damage the lung tissues/cardiac function. However, physical (aerobic and/or resistance) exercise-induced release of heat shock protein, immune function alteration or reduced tissue hypoxia, have been highlighted as possible mechanisms by which increasing physical activity may reduce plasma pro-inflammatory cytokines in uninfected individuals and should be appraised in the literature for evidence of similar benefits in people living with HIV (PLWH). Therefore, we evaluated the effects of physical exercises on 1) inflammatory biomarkers and 2) cardiopulmonary function (VO2 Max) in PLWH. Method A systematic review was conducted using the Cochrane Collaboration protocol. Searching databases, up to January 2018. Only randomized control trials investigating the effects of either aerobic or resistance or a combination of both exercise types with a control/other intervention(s) for a period of at least 4 weeks among adults living with HIV, were included. Two independent reviewers determined the eligibility of the studies. Data were extracted and risk of bias (ROB) was assessed with the Cochrane Collaboration ROB tool. Meta-analyses were conducted with random effect models using the Review Manager (RevMan) computer software. Result Twenty-three studies met inclusion criteria (n = 1073 participants at study completion) comprising male and female with age range 18–65 years. Three meta-analyses across three sub-groups comparisons were performed. The result showed no significant change in biomarkers of inflammation (IL-6 and IL-1β) unlike a significant (Z = 3.80, p < 0.0001) improvement in VO2 Max. Overall, the GRADE evidence for this review was of moderate quality. Conclusion There was evidence that engaging in either aerobic or resistance exercise, or a combination of both exercises, two to five times per week can lead to a significant improvement in cardiopulmonary function but not biomarkers of inflammation (IL-6 and IL-1β). However, this should not be interpreted as “No evidence of effect” because the individual trial studies did not attain sufficient power to detect treatment effects. The moderate grade evidence for this review suggests that further research may likely have an important impact on our confidence in the estimate of effects and may change the estimate.http://link.springer.com/article/10.1186/s12879-019-3960-0Physical exercisesAerobic exercisesResistance exercisesHuman immunodeficiency virusPatients living with HIVHighly active antiretroviral therapy |
| spellingShingle | S. C. Ibeneme C. Omeje H. Myezwa Salome Nwaelom Ezeofor E. M. Anieto F. Irem Amaka Obiageli Nnamani Fortune Elochukwu Ezenwankwo G. C. Ibeneme Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: a systematic review with meta-analysis BMC Infectious Diseases Physical exercises Aerobic exercises Resistance exercises Human immunodeficiency virus Patients living with HIV Highly active antiretroviral therapy |
| title | Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: a systematic review with meta-analysis |
| title_full | Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: a systematic review with meta-analysis |
| title_fullStr | Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: a systematic review with meta-analysis |
| title_full_unstemmed | Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: a systematic review with meta-analysis |
| title_short | Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: a systematic review with meta-analysis |
| title_sort | effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with hiv a systematic review with meta analysis |
| topic | Physical exercises Aerobic exercises Resistance exercises Human immunodeficiency virus Patients living with HIV Highly active antiretroviral therapy |
| url | http://link.springer.com/article/10.1186/s12879-019-3960-0 |
| work_keys_str_mv | AT scibeneme effectsofphysicalexercisesoninflammatorybiomarkersandcardiopulmonaryfunctioninpatientslivingwithhivasystematicreviewwithmetaanalysis AT comeje effectsofphysicalexercisesoninflammatorybiomarkersandcardiopulmonaryfunctioninpatientslivingwithhivasystematicreviewwithmetaanalysis AT hmyezwa effectsofphysicalexercisesoninflammatorybiomarkersandcardiopulmonaryfunctioninpatientslivingwithhivasystematicreviewwithmetaanalysis AT salomenwaelomezeofor effectsofphysicalexercisesoninflammatorybiomarkersandcardiopulmonaryfunctioninpatientslivingwithhivasystematicreviewwithmetaanalysis AT emanieto effectsofphysicalexercisesoninflammatorybiomarkersandcardiopulmonaryfunctioninpatientslivingwithhivasystematicreviewwithmetaanalysis AT firem effectsofphysicalexercisesoninflammatorybiomarkersandcardiopulmonaryfunctioninpatientslivingwithhivasystematicreviewwithmetaanalysis AT amakaobiagelinnamani effectsofphysicalexercisesoninflammatorybiomarkersandcardiopulmonaryfunctioninpatientslivingwithhivasystematicreviewwithmetaanalysis AT fortuneelochukwuezenwankwo effectsofphysicalexercisesoninflammatorybiomarkersandcardiopulmonaryfunctioninpatientslivingwithhivasystematicreviewwithmetaanalysis AT gcibeneme effectsofphysicalexercisesoninflammatorybiomarkersandcardiopulmonaryfunctioninpatientslivingwithhivasystematicreviewwithmetaanalysis |