Differentiating antiepiligrin cicatricial pemphigoid from epidermolysis bullosa acquisita by indirect immunofluorescence of skin substrates lacking Type VII collagen or laminin 332: a case report and review of literature
Antiepiligrin cicatricial pemphigoid (AECP) is a chronic autoimmune subepidermal blistering disease characterized by clinical features of cicatricial pemphigoid and circulating IgG antibasement membrane autoantibodies directed against laminin 332. There is growing evidence of an increased relative r...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-06-01
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| Series: | Dermatologica Sinica |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1027811711000334 |
| _version_ | 1818025560043945984 |
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| author | Chih-Pin Chen Richard Plunkett Raminder Grover Song-Jen Hong |
| author_facet | Chih-Pin Chen Richard Plunkett Raminder Grover Song-Jen Hong |
| author_sort | Chih-Pin Chen |
| collection | DOAJ |
| description | Antiepiligrin cicatricial pemphigoid (AECP) is a chronic autoimmune subepidermal blistering disease characterized by clinical features of cicatricial pemphigoid and circulating IgG antibasement membrane autoantibodies directed against laminin 332. There is growing evidence of an increased relative risk for solid cancers and lymphomas in AECP patients, especially in the 1st year after the onset of blisters. However, it is difficult to distinguish patients with initially skin-predominant AECP from similar findings of epidermolysis bullosa acquisita merely based on clinical, histopathologic, and immuno-pathologic examinations. This is a report on a case of AECP confirmed by indirect immunofluorescence of type VII collagen- and laminin 332-deficient skin as substrates to differentiate it from epidermolysis bullosa acquisita. |
| first_indexed | 2024-12-10T04:18:03Z |
| format | Article |
| id | doaj.art-4a89363dbc234aa69a6dc81cbff83d2b |
| institution | Directory Open Access Journal |
| issn | 1027-8117 |
| language | English |
| last_indexed | 2024-12-10T04:18:03Z |
| publishDate | 2011-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dermatologica Sinica |
| spelling | doaj.art-4a89363dbc234aa69a6dc81cbff83d2b2022-12-22T02:02:31ZengWolters Kluwer Medknow PublicationsDermatologica Sinica1027-81172011-06-01292555810.1016/j.dsi.2011.05.003Differentiating antiepiligrin cicatricial pemphigoid from epidermolysis bullosa acquisita by indirect immunofluorescence of skin substrates lacking Type VII collagen or laminin 332: a case report and review of literatureChih-Pin Chen0Richard Plunkett1Raminder Grover2Song-Jen Hong3Department of Dermatology, Buddhist Tzu-Chi General Hospital, Hualien, TaiwanDepartment of Microbiology and Immunology, School of Medicine, State University of New York at Buffalo, Buffalo, New York, NY, USADepartment of Microbiology and Immunology, School of Medicine, State University of New York at Buffalo, Buffalo, New York, NY, USADepartment of Dermatology, Buddhist Tzu-Chi General Hospital, Hualien, TaiwanAntiepiligrin cicatricial pemphigoid (AECP) is a chronic autoimmune subepidermal blistering disease characterized by clinical features of cicatricial pemphigoid and circulating IgG antibasement membrane autoantibodies directed against laminin 332. There is growing evidence of an increased relative risk for solid cancers and lymphomas in AECP patients, especially in the 1st year after the onset of blisters. However, it is difficult to distinguish patients with initially skin-predominant AECP from similar findings of epidermolysis bullosa acquisita merely based on clinical, histopathologic, and immuno-pathologic examinations. This is a report on a case of AECP confirmed by indirect immunofluorescence of type VII collagen- and laminin 332-deficient skin as substrates to differentiate it from epidermolysis bullosa acquisita.http://www.sciencedirect.com/science/article/pii/S1027811711000334Antiepiligrin cicatricial pemphigoidEpidermolysis bullosa acquisitaIndirect immunofluorescenceLaminin 332Type VII collagen |
| spellingShingle | Chih-Pin Chen Richard Plunkett Raminder Grover Song-Jen Hong Differentiating antiepiligrin cicatricial pemphigoid from epidermolysis bullosa acquisita by indirect immunofluorescence of skin substrates lacking Type VII collagen or laminin 332: a case report and review of literature Dermatologica Sinica Antiepiligrin cicatricial pemphigoid Epidermolysis bullosa acquisita Indirect immunofluorescence Laminin 332 Type VII collagen |
| title | Differentiating antiepiligrin cicatricial pemphigoid from epidermolysis bullosa acquisita by indirect immunofluorescence of skin substrates lacking Type VII collagen or laminin 332: a case report and review of literature |
| title_full | Differentiating antiepiligrin cicatricial pemphigoid from epidermolysis bullosa acquisita by indirect immunofluorescence of skin substrates lacking Type VII collagen or laminin 332: a case report and review of literature |
| title_fullStr | Differentiating antiepiligrin cicatricial pemphigoid from epidermolysis bullosa acquisita by indirect immunofluorescence of skin substrates lacking Type VII collagen or laminin 332: a case report and review of literature |
| title_full_unstemmed | Differentiating antiepiligrin cicatricial pemphigoid from epidermolysis bullosa acquisita by indirect immunofluorescence of skin substrates lacking Type VII collagen or laminin 332: a case report and review of literature |
| title_short | Differentiating antiepiligrin cicatricial pemphigoid from epidermolysis bullosa acquisita by indirect immunofluorescence of skin substrates lacking Type VII collagen or laminin 332: a case report and review of literature |
| title_sort | differentiating antiepiligrin cicatricial pemphigoid from epidermolysis bullosa acquisita by indirect immunofluorescence of skin substrates lacking type vii collagen or laminin 332 a case report and review of literature |
| topic | Antiepiligrin cicatricial pemphigoid Epidermolysis bullosa acquisita Indirect immunofluorescence Laminin 332 Type VII collagen |
| url | http://www.sciencedirect.com/science/article/pii/S1027811711000334 |
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