Injectable self-assembled GDF5-containing dipeptide hydrogels for enhanced tendon repair
Owing to the tissue characteristics of tendons with few blood vessels and cells, the regeneration and repair of injured tendons can present a considerable challenge, which considerably affects the motor function of limbs and leads to serious physical and mental pain, along with an economic burden on...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424001054 |
| _version_ | 1797220255673614336 |
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| author | Ming Zhang Hao Wang Guan-Chun Dai Pan-Pan Lu Yu-Cheng Gao Mu-Ming Cao Ying-Juan Li Yun-Feng Rui |
| author_facet | Ming Zhang Hao Wang Guan-Chun Dai Pan-Pan Lu Yu-Cheng Gao Mu-Ming Cao Ying-Juan Li Yun-Feng Rui |
| author_sort | Ming Zhang |
| collection | DOAJ |
| description | Owing to the tissue characteristics of tendons with few blood vessels and cells, the regeneration and repair of injured tendons can present a considerable challenge, which considerably affects the motor function of limbs and leads to serious physical and mental pain, along with an economic burden on patients. Herein, we designed and fabricated a dipeptide hydrogel (DPH) using polypeptides P11-4 and P11-8. This hydrogel exhibited self-assembly characteristics and could be administered in vitro. To endow the hydrogel with differentiation and regeneration abilities, we added different concentrations of growth differentiation factor 5 (GDF5) to form GDF5@DPH. GDF5@DPH promoted the aggregation and differentiation of tendon stem/progenitor cells and promoted the regeneration and repair of tendon cells and collagen fibers in injured areas. In addition, GDF5@DPH inhibited inflammatory reactions in the injured area. Owing to its injectable properties, DPH can jointly inhibit adhesion and scar hyperplasia between tissues caused by endogenous inflammation and exogenous surgery and can provide a favorable internal environment for the regeneration and repair of the injured area. Overall, the GDF5@DPH system exhibits considerable promise as a novel approach to treating tendon injury. |
| first_indexed | 2024-04-24T12:46:38Z |
| format | Article |
| id | doaj.art-4a8b82664a284c70ae9da1760594edf2 |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-04-24T12:46:38Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-4a8b82664a284c70ae9da1760594edf22024-04-07T04:36:12ZengElsevierMaterials Today Bio2590-00642024-06-0126101046Injectable self-assembled GDF5-containing dipeptide hydrogels for enhanced tendon repairMing Zhang0Hao Wang1Guan-Chun Dai2Pan-Pan Lu3Yu-Cheng Gao4Mu-Ming Cao5Ying-Juan Li6Yun-Feng Rui7Department of Orthopedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, PR China; School of Medicine, Southeast University, Nanjing, Jiangsu, PR China; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu, PR China; Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, PR ChinaDepartment of Orthopedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, PR China; School of Medicine, Southeast University, Nanjing, Jiangsu, PR China; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu, PR China; Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, PR ChinaDepartment of Orthopedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, PR China; School of Medicine, Southeast University, Nanjing, Jiangsu, PR China; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu, PR China; Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, PR ChinaDepartment of Orthopedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, PR China; School of Medicine, Southeast University, Nanjing, Jiangsu, PR China; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu, PR China; Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, PR ChinaDepartment of Orthopedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, PR China; School of Medicine, Southeast University, Nanjing, Jiangsu, PR China; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu, PR China; Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, PR ChinaDepartment of Orthopedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, PR China; School of Medicine, Southeast University, Nanjing, Jiangsu, PR China; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu, PR China; Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, PR ChinaDepartment of Geriatrics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, PR ChinaDepartment of Orthopedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, PR China; School of Medicine, Southeast University, Nanjing, Jiangsu, PR China; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu, PR China; Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, PR China; Corresponding author. Department of Orthopedics, Zhongda Hospital& School of Medicine, Southeast University, 87 Dingjiaqiao, Nanjing, Jiangsu, 210003, PR China.Owing to the tissue characteristics of tendons with few blood vessels and cells, the regeneration and repair of injured tendons can present a considerable challenge, which considerably affects the motor function of limbs and leads to serious physical and mental pain, along with an economic burden on patients. Herein, we designed and fabricated a dipeptide hydrogel (DPH) using polypeptides P11-4 and P11-8. This hydrogel exhibited self-assembly characteristics and could be administered in vitro. To endow the hydrogel with differentiation and regeneration abilities, we added different concentrations of growth differentiation factor 5 (GDF5) to form GDF5@DPH. GDF5@DPH promoted the aggregation and differentiation of tendon stem/progenitor cells and promoted the regeneration and repair of tendon cells and collagen fibers in injured areas. In addition, GDF5@DPH inhibited inflammatory reactions in the injured area. Owing to its injectable properties, DPH can jointly inhibit adhesion and scar hyperplasia between tissues caused by endogenous inflammation and exogenous surgery and can provide a favorable internal environment for the regeneration and repair of the injured area. Overall, the GDF5@DPH system exhibits considerable promise as a novel approach to treating tendon injury.http://www.sciencedirect.com/science/article/pii/S2590006424001054Tendon stem/progenitor cellsDipeptide hydrogelSelf-assemblyGrowth differentiation factor 5Tendon repair |
| spellingShingle | Ming Zhang Hao Wang Guan-Chun Dai Pan-Pan Lu Yu-Cheng Gao Mu-Ming Cao Ying-Juan Li Yun-Feng Rui Injectable self-assembled GDF5-containing dipeptide hydrogels for enhanced tendon repair Materials Today Bio Tendon stem/progenitor cells Dipeptide hydrogel Self-assembly Growth differentiation factor 5 Tendon repair |
| title | Injectable self-assembled GDF5-containing dipeptide hydrogels for enhanced tendon repair |
| title_full | Injectable self-assembled GDF5-containing dipeptide hydrogels for enhanced tendon repair |
| title_fullStr | Injectable self-assembled GDF5-containing dipeptide hydrogels for enhanced tendon repair |
| title_full_unstemmed | Injectable self-assembled GDF5-containing dipeptide hydrogels for enhanced tendon repair |
| title_short | Injectable self-assembled GDF5-containing dipeptide hydrogels for enhanced tendon repair |
| title_sort | injectable self assembled gdf5 containing dipeptide hydrogels for enhanced tendon repair |
| topic | Tendon stem/progenitor cells Dipeptide hydrogel Self-assembly Growth differentiation factor 5 Tendon repair |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424001054 |
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