Gut Microbiota, Leaky Gut, and Autoimmune Diseases
With the rising prevalence of autoimmune diseases, the role of the environment, specifically the gut microbiota, in disease development has grown to be a major area of study. Recent advances show a relationship and possible cause and effect between the gut microbiota and the initiation or exacerbati...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.946248/full |
| _version_ | 1811333943139500032 |
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| author | Anna Christovich Xin M. Luo |
| author_facet | Anna Christovich Xin M. Luo |
| author_sort | Anna Christovich |
| collection | DOAJ |
| description | With the rising prevalence of autoimmune diseases, the role of the environment, specifically the gut microbiota, in disease development has grown to be a major area of study. Recent advances show a relationship and possible cause and effect between the gut microbiota and the initiation or exacerbation of autoimmune diseases. Furthermore, microbial dysbiosis and leaky gut are frequent phenomena in both human autoimmune diseases and the murine autoimmunity models. This review will focus on literature in recent years concerning the gut microbiota and leaky gut in relation to the autoimmune diseases, including systemic lupus erythematosus, type 1 diabetes, and multiple sclerosis. |
| first_indexed | 2024-04-13T17:00:20Z |
| format | Article |
| id | doaj.art-4a90d0383d0343fb973d00b881d92efb |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T17:00:20Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-4a90d0383d0343fb973d00b881d92efb2022-12-22T02:38:41ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-06-011310.3389/fimmu.2022.946248946248Gut Microbiota, Leaky Gut, and Autoimmune DiseasesAnna Christovich0Xin M. Luo1Department of Biological Systems Engineering, Virginia Tech, Blacksburg, VA, United StatesDepartment of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, VA, United StatesWith the rising prevalence of autoimmune diseases, the role of the environment, specifically the gut microbiota, in disease development has grown to be a major area of study. Recent advances show a relationship and possible cause and effect between the gut microbiota and the initiation or exacerbation of autoimmune diseases. Furthermore, microbial dysbiosis and leaky gut are frequent phenomena in both human autoimmune diseases and the murine autoimmunity models. This review will focus on literature in recent years concerning the gut microbiota and leaky gut in relation to the autoimmune diseases, including systemic lupus erythematosus, type 1 diabetes, and multiple sclerosis.https://www.frontiersin.org/articles/10.3389/fimmu.2022.946248/fullgut microbiotaleaky gutsystemic lupus erythematosustype 1 diabetesmultiple sclerosis |
| spellingShingle | Anna Christovich Xin M. Luo Gut Microbiota, Leaky Gut, and Autoimmune Diseases Frontiers in Immunology gut microbiota leaky gut systemic lupus erythematosus type 1 diabetes multiple sclerosis |
| title | Gut Microbiota, Leaky Gut, and Autoimmune Diseases |
| title_full | Gut Microbiota, Leaky Gut, and Autoimmune Diseases |
| title_fullStr | Gut Microbiota, Leaky Gut, and Autoimmune Diseases |
| title_full_unstemmed | Gut Microbiota, Leaky Gut, and Autoimmune Diseases |
| title_short | Gut Microbiota, Leaky Gut, and Autoimmune Diseases |
| title_sort | gut microbiota leaky gut and autoimmune diseases |
| topic | gut microbiota leaky gut systemic lupus erythematosus type 1 diabetes multiple sclerosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.946248/full |
| work_keys_str_mv | AT annachristovich gutmicrobiotaleakygutandautoimmunediseases AT xinmluo gutmicrobiotaleakygutandautoimmunediseases |