Exosomes in craniofacial tissue reconstruction
Abstract Background Mesenchymal stem cell (MSC) therapy gained interest among scientists following the discovery of its therapeutic potential. However, their clinical use has been hindered due to their immunogenicity and tumorigenicity. Relatively recently, it has been unveiled that the mechanism by...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-08-01
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| Series: | Maxillofacial Plastic and Reconstructive Surgery |
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| Online Access: | https://doi.org/10.1186/s40902-022-00357-3 |
| _version_ | 1828356508625141760 |
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| author | Muhja Salah Farhad B. Naini |
| author_facet | Muhja Salah Farhad B. Naini |
| author_sort | Muhja Salah |
| collection | DOAJ |
| description | Abstract Background Mesenchymal stem cell (MSC) therapy gained interest among scientists following the discovery of its therapeutic potential. However, their clinical use has been hindered due to their immunogenicity and tumorigenicity. Relatively recently, it has been unveiled that the mechanism by which MSC promote healing is by secreting exosomes. This raised the interest in developing cell-free therapy, avoiding the obstacles that deterred the translation of MSC therapy into clinical practice. Review This comprehensive narrative review summarises the current understanding of exosome biogenesis and content. Moreover, the existing research on exosome use in bone tissue engineering is discussed. Conclusions Exosome-based therapy may provide excellent potential in the field of bone tissue engineering and craniofacial reconstructive surgery. Further investigation is required before the technology can be translated into clinical practice. |
| first_indexed | 2024-04-14T03:01:18Z |
| format | Article |
| id | doaj.art-4a91561dd3534f7b9d638f7bb17fb297 |
| institution | Directory Open Access Journal |
| issn | 2288-8586 |
| language | English |
| last_indexed | 2024-04-14T03:01:18Z |
| publishDate | 2022-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Maxillofacial Plastic and Reconstructive Surgery |
| spelling | doaj.art-4a91561dd3534f7b9d638f7bb17fb2972022-12-22T02:15:54ZengSpringerOpenMaxillofacial Plastic and Reconstructive Surgery2288-85862022-08-014411710.1186/s40902-022-00357-3Exosomes in craniofacial tissue reconstructionMuhja Salah0Farhad B. Naini1Centre for Additive Manufacturing, University of NottinghamKingston and St George’s University HospitalsAbstract Background Mesenchymal stem cell (MSC) therapy gained interest among scientists following the discovery of its therapeutic potential. However, their clinical use has been hindered due to their immunogenicity and tumorigenicity. Relatively recently, it has been unveiled that the mechanism by which MSC promote healing is by secreting exosomes. This raised the interest in developing cell-free therapy, avoiding the obstacles that deterred the translation of MSC therapy into clinical practice. Review This comprehensive narrative review summarises the current understanding of exosome biogenesis and content. Moreover, the existing research on exosome use in bone tissue engineering is discussed. Conclusions Exosome-based therapy may provide excellent potential in the field of bone tissue engineering and craniofacial reconstructive surgery. Further investigation is required before the technology can be translated into clinical practice.https://doi.org/10.1186/s40902-022-00357-3Bone tissue engineeringMesenchymal stem cellsExosomesBiogenesis and tissue bone scaffolds |
| spellingShingle | Muhja Salah Farhad B. Naini Exosomes in craniofacial tissue reconstruction Maxillofacial Plastic and Reconstructive Surgery Bone tissue engineering Mesenchymal stem cells Exosomes Biogenesis and tissue bone scaffolds |
| title | Exosomes in craniofacial tissue reconstruction |
| title_full | Exosomes in craniofacial tissue reconstruction |
| title_fullStr | Exosomes in craniofacial tissue reconstruction |
| title_full_unstemmed | Exosomes in craniofacial tissue reconstruction |
| title_short | Exosomes in craniofacial tissue reconstruction |
| title_sort | exosomes in craniofacial tissue reconstruction |
| topic | Bone tissue engineering Mesenchymal stem cells Exosomes Biogenesis and tissue bone scaffolds |
| url | https://doi.org/10.1186/s40902-022-00357-3 |
| work_keys_str_mv | AT muhjasalah exosomesincraniofacialtissuereconstruction AT farhadbnaini exosomesincraniofacialtissuereconstruction |