PPARγ Acetylation in Adipocytes Exacerbates BAT Whitening and Worsens Age-Associated Metabolic Dysfunction

PPARγ Acetylation in Adipocytes Exacerbates BAT Whitening and Worsens Age-Associated Metabolic Dysfunction

Aging and obesity are the two prominent driving forces of metabolic dysfunction, yet the common underlying mechanisms remain elusive. PPARγ, a central metabolic regulator and primary drug target combatting insulin resistance, is hyperacetylated in both aging and obesity. By employing a unique adipoc...

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Bibliographic Details
Main Authors: Ying He, Ruotong Zhang, Lexiang Yu, Tarik Zahr, Xueming Li, Tae-Wan Kim, Li Qiang
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cells
Subjects:
PPARγ acetylation
brown adipose tissue
whitening
metabolic dysfunction
Online Access:https://www.mdpi.com/2073-4409/12/10/1424

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