Efficient Production of Fc Fusion Proteins in the Cytoplasm of <i>Escherichia coli</i>: Dissecting and Mitigating Redox Heterogeneity

Efficient Production of Fc Fusion Proteins in the Cytoplasm of <i>Escherichia coli</i>: Dissecting and Mitigating Redox Heterogeneity

Cost-effective production of therapeutic proteins in microbial hosts is an indispensable tool towards accessible healthcare. Many of these heterologously expressed proteins, including all antibody formats, require disulfide bond formation to attain their native and functional state. A system for cat...

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Bibliographic Details
Main Authors:	Aatir A. Tungekar, Lloyd W. Ruddock
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Series:	International Journal of Molecular Sciences
Subjects:	<i>Escherichia coli</i> CyDisCo system Fc fusion proteins redox heterogeneity oxidative folding
Online Access:	https://www.mdpi.com/1422-0067/23/23/14740

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