Targeted next-generation sequencing assays using triplet samples of normal breast tissue, primary breast cancer, and recurrent/metastatic lesions

Targeted next-generation sequencing assays using triplet samples of normal breast tissue, primary breast cancer, and recurrent/metastatic lesions

Abstract Background Next-generation sequencing (NGS) has shown that recurrent/metastatic breast cancer lesions may have additional genetic changes compared with the primary tumor. These additional changes may be related to tumor progression and/or drug resistance. However, breast cancer-targeted NGS...

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Bibliographic Details
Main Authors: Toshiaki Akahane, Naoki Kanomata, Oi Harada, Tetsumasa Yamashita, Junichi Kurebayashi, Akihide Tanimoto, Takuya Moriya
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Cancer
Subjects:
Breast cancer
Metastasis
Recurrence
Next-generation sequencing
Online Access:http://link.springer.com/article/10.1186/s12885-020-07432-w

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