Nano‐therapeutic strategies to target coronavirus
Abstract The coronaviruses have caused severe acute respiratory syndrome (SARS), the Middle East respiratory syndrome (MERS), and the more recent coronavirus pneumonia (COVID‐19). The global COVID‐19 pandemic requires urgent action to develop anti‐virals, new therapeutics, and vaccines. In this revi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-06-01
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| Series: | View |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/VIW.20200155 |
| _version_ | 1819045253014880256 |
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| author | Mohd Ahmar Rauf Munazzah Tasleem Ketki Bhise Katyayani Tatiparti Samaresh Sau Arun K. Iyer |
| author_facet | Mohd Ahmar Rauf Munazzah Tasleem Ketki Bhise Katyayani Tatiparti Samaresh Sau Arun K. Iyer |
| author_sort | Mohd Ahmar Rauf |
| collection | DOAJ |
| description | Abstract The coronaviruses have caused severe acute respiratory syndrome (SARS), the Middle East respiratory syndrome (MERS), and the more recent coronavirus pneumonia (COVID‐19). The global COVID‐19 pandemic requires urgent action to develop anti‐virals, new therapeutics, and vaccines. In this review, we discuss potential therapeutics including human recombinant ACE2 soluble, inflammatory cytokine inhibitors, and direct anti‐viral agents such as remdesivir and favipiravir, to limit their fatality. We also discuss the structure of the SARS‐CoV‐2, which is crucial to the timely development of therapeutics, and previous attempts to generate vaccines against SARS‐CoV and MERS‐CoV. Finally, we provide an overview of the role of nanotechnology in the development of therapeutics as well as in the diagnosis of the infection. This information is key for computational modeling and nanomedicine‐based new therapeutics by counteracting the variable proteins in the virus. Further, we also try to effectively share the latest information about many different aspects of COVID‐19 vaccine developments and possible management to further scientific endeavors. |
| first_indexed | 2024-12-21T10:25:38Z |
| format | Article |
| id | doaj.art-4a949c7ba568402ea6db53e89e7e9a14 |
| institution | Directory Open Access Journal |
| issn | 2688-3988 2688-268X |
| language | English |
| last_indexed | 2024-12-21T10:25:38Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | View |
| spelling | doaj.art-4a949c7ba568402ea6db53e89e7e9a142022-12-21T19:07:19ZengWileyView2688-39882688-268X2021-06-0123n/an/a10.1002/VIW.20200155Nano‐therapeutic strategies to target coronavirusMohd Ahmar Rauf0Munazzah Tasleem1Ketki Bhise2Katyayani Tatiparti3Samaresh Sau4Arun K. Iyer5Use‐inspired Biomaterials & Integrated Nano Delivery (U‐BiND) Systems Laboratory Department of Pharmaceutical Sciences Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University Detroit MichiganBioinformatics Infrastructure Facility, Department of Computer Science Jamia Millia Islamia University New Delhi 110025 IndiaUse‐inspired Biomaterials & Integrated Nano Delivery (U‐BiND) Systems Laboratory Department of Pharmaceutical Sciences Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University Detroit MichiganUse‐inspired Biomaterials & Integrated Nano Delivery (U‐BiND) Systems Laboratory Department of Pharmaceutical Sciences Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University Detroit MichiganUse‐inspired Biomaterials & Integrated Nano Delivery (U‐BiND) Systems Laboratory Department of Pharmaceutical Sciences Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University Detroit MichiganUse‐inspired Biomaterials & Integrated Nano Delivery (U‐BiND) Systems Laboratory Department of Pharmaceutical Sciences Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University Detroit MichiganAbstract The coronaviruses have caused severe acute respiratory syndrome (SARS), the Middle East respiratory syndrome (MERS), and the more recent coronavirus pneumonia (COVID‐19). The global COVID‐19 pandemic requires urgent action to develop anti‐virals, new therapeutics, and vaccines. In this review, we discuss potential therapeutics including human recombinant ACE2 soluble, inflammatory cytokine inhibitors, and direct anti‐viral agents such as remdesivir and favipiravir, to limit their fatality. We also discuss the structure of the SARS‐CoV‐2, which is crucial to the timely development of therapeutics, and previous attempts to generate vaccines against SARS‐CoV and MERS‐CoV. Finally, we provide an overview of the role of nanotechnology in the development of therapeutics as well as in the diagnosis of the infection. This information is key for computational modeling and nanomedicine‐based new therapeutics by counteracting the variable proteins in the virus. Further, we also try to effectively share the latest information about many different aspects of COVID‐19 vaccine developments and possible management to further scientific endeavors.https://doi.org/10.1002/VIW.202001552019‐nCoVcoronavirusCOVID‐19nanotechnologySARS‐CoV‐2vaccine development |
| spellingShingle | Mohd Ahmar Rauf Munazzah Tasleem Ketki Bhise Katyayani Tatiparti Samaresh Sau Arun K. Iyer Nano‐therapeutic strategies to target coronavirus View 2019‐nCoV coronavirus COVID‐19 nanotechnology SARS‐CoV‐2 vaccine development |
| title | Nano‐therapeutic strategies to target coronavirus |
| title_full | Nano‐therapeutic strategies to target coronavirus |
| title_fullStr | Nano‐therapeutic strategies to target coronavirus |
| title_full_unstemmed | Nano‐therapeutic strategies to target coronavirus |
| title_short | Nano‐therapeutic strategies to target coronavirus |
| title_sort | nano therapeutic strategies to target coronavirus |
| topic | 2019‐nCoV coronavirus COVID‐19 nanotechnology SARS‐CoV‐2 vaccine development |
| url | https://doi.org/10.1002/VIW.20200155 |
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