Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction
2- arachidonoylglycerol (2-AG), an abundant endocannabinoid in the brain, regulates diverse neural functions. Here, the authors identified four loss-of-function mutations in dicylglycerol lipase β (DAGLB) from six patients with early onset Parkinsonism. In mice, loss of DAGLB in dopamine neurons red...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31168-9 |
| _version_ | 1818252141262798848 |
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| author | Zhenhua Liu Nannan Yang Jie Dong Wotu Tian Lisa Chang Jinghong Ma Jifeng Guo Jieqiong Tan Ao Dong Kaikai He Jingheng Zhou Resat Cinar Junbing Wu Armando G. Salinas Lixin Sun Mantosh Kumar Breanna T. Sullivan Braden B. Oldham Vanessa Pitz Mary B. Makarious Jinhui Ding Justin Kung Chengsong Xie Sarah L. Hawes Lupeng Wang Tao Wang Piu Chan Zhuohua Zhang Weidong Le Shengdi Chen David M. Lovinger Cornelis Blauwendraat Andrew B. Singleton Guohong Cui Yulong Li Huaibin Cai Beisha Tang |
| author_facet | Zhenhua Liu Nannan Yang Jie Dong Wotu Tian Lisa Chang Jinghong Ma Jifeng Guo Jieqiong Tan Ao Dong Kaikai He Jingheng Zhou Resat Cinar Junbing Wu Armando G. Salinas Lixin Sun Mantosh Kumar Breanna T. Sullivan Braden B. Oldham Vanessa Pitz Mary B. Makarious Jinhui Ding Justin Kung Chengsong Xie Sarah L. Hawes Lupeng Wang Tao Wang Piu Chan Zhuohua Zhang Weidong Le Shengdi Chen David M. Lovinger Cornelis Blauwendraat Andrew B. Singleton Guohong Cui Yulong Li Huaibin Cai Beisha Tang |
| author_sort | Zhenhua Liu |
| collection | DOAJ |
| description | 2- arachidonoylglycerol (2-AG), an abundant endocannabinoid in the brain, regulates diverse neural functions. Here, the authors identified four loss-of-function mutations in dicylglycerol lipase β (DAGLB) from six patients with early onset Parkinsonism. In mice, loss of DAGLB in dopamine neurons reduced neuronal activity and impaired locomotor function and augmentation of 2-AG levels boosted neuronal activity and rescued locomotor deficits. |
| first_indexed | 2024-12-12T16:19:27Z |
| format | Article |
| id | doaj.art-4a94e3b86d214217aab9a2b47dae2413 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T16:19:27Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4a94e3b86d214217aab9a2b47dae24132022-12-22T00:19:01ZengNature PortfolioNature Communications2041-17232022-06-0113111610.1038/s41467-022-31168-9Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunctionZhenhua Liu0Nannan Yang1Jie Dong2Wotu Tian3Lisa Chang4Jinghong Ma5Jifeng Guo6Jieqiong Tan7Ao Dong8Kaikai He9Jingheng Zhou10Resat Cinar11Junbing Wu12Armando G. Salinas13Lixin Sun14Mantosh Kumar15Breanna T. Sullivan16Braden B. Oldham17Vanessa Pitz18Mary B. Makarious19Jinhui Ding20Justin Kung21Chengsong Xie22Sarah L. Hawes23Lupeng Wang24Tao Wang25Piu Chan26Zhuohua Zhang27Weidong Le28Shengdi Chen29David M. Lovinger30Cornelis Blauwendraat31Andrew B. Singleton32Guohong Cui33Yulong Li34Huaibin Cai35Beisha Tang36Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthDepartment of Neurology, Xuanwu Hospital of Capital Medical UniversityDepartment of Neurology, Xiangya Hospital, Central South UniversityCentre for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South UniversityState Key Laboratory of Membrane Biology, Peking University School of Life SciencesState Key Laboratory of Membrane Biology, Peking University School of Life SciencesIn Vivo Neurobiology Group, Neurobiology Laboratory, National Institute of Environmental Health SciencesLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of HealthTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthLaboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of HealthTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthMolecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthMolecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthComputational Biology Group, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Xuanwu Hospital of Capital Medical UniversityCentre for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South UniversityClinical Research Center on Neurological Diseases, the First Affiliated Hospital, Dalian Medical UniversityDepartment of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineLaboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of HealthIntegrative Neurogenomics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthMolecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthIn Vivo Neurobiology Group, Neurobiology Laboratory, National Institute of Environmental Health SciencesState Key Laboratory of Membrane Biology, Peking University School of Life SciencesTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthDepartment of Neurology, Xiangya Hospital, Central South University2- arachidonoylglycerol (2-AG), an abundant endocannabinoid in the brain, regulates diverse neural functions. Here, the authors identified four loss-of-function mutations in dicylglycerol lipase β (DAGLB) from six patients with early onset Parkinsonism. In mice, loss of DAGLB in dopamine neurons reduced neuronal activity and impaired locomotor function and augmentation of 2-AG levels boosted neuronal activity and rescued locomotor deficits.https://doi.org/10.1038/s41467-022-31168-9 |
| spellingShingle | Zhenhua Liu Nannan Yang Jie Dong Wotu Tian Lisa Chang Jinghong Ma Jifeng Guo Jieqiong Tan Ao Dong Kaikai He Jingheng Zhou Resat Cinar Junbing Wu Armando G. Salinas Lixin Sun Mantosh Kumar Breanna T. Sullivan Braden B. Oldham Vanessa Pitz Mary B. Makarious Jinhui Ding Justin Kung Chengsong Xie Sarah L. Hawes Lupeng Wang Tao Wang Piu Chan Zhuohua Zhang Weidong Le Shengdi Chen David M. Lovinger Cornelis Blauwendraat Andrew B. Singleton Guohong Cui Yulong Li Huaibin Cai Beisha Tang Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction Nature Communications |
| title | Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction |
| title_full | Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction |
| title_fullStr | Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction |
| title_full_unstemmed | Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction |
| title_short | Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction |
| title_sort | deficiency in endocannabinoid synthase daglb contributes to early onset parkinsonism and murine nigral dopaminergic neuron dysfunction |
| url | https://doi.org/10.1038/s41467-022-31168-9 |
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