A conducting polymer-based array with multiplex sensing and drug delivery capabilities for smart bandages
Abstract Effective individual wound management, particularly in cases of prolonged healing and increased infection vulnerability, has prompted the development of wound theranostics, combining real-time diagnostic assessment and on-demand treatment. Here, we present a multifunctional conducting polym...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-03-01
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| Series: | Communications Materials |
| Online Access: | https://doi.org/10.1038/s43246-024-00469-5 |
| _version_ | 1797259142184828928 |
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| author | Lingyin Meng Sheng Liu Baris Ata Borsa Mats Eriksson Wing Cheung Mak |
| author_facet | Lingyin Meng Sheng Liu Baris Ata Borsa Mats Eriksson Wing Cheung Mak |
| author_sort | Lingyin Meng |
| collection | DOAJ |
| description | Abstract Effective individual wound management, particularly in cases of prolonged healing and increased infection vulnerability, has prompted the development of wound theranostics, combining real-time diagnostic assessment and on-demand treatment. Here, we present a multifunctional conducting polymer-based smart theranostic bandage that integrates pH sensing, pH-compensated uric acid (UA) biosensing, and on-demand antibiotic release using different conducting polymers, each leveraging their advantageous intrinsic properties. Specifically, the polyaniline-based pH sensor operates reversibly across a pH range of 4–10, while the functionalized poly(3,4-ethylenedioxythiophene)-based UA biosensor exhibits a linear response up to 0.9 mM UA. Simultaneous detection of pH and UA allows accurate UA determination via pH compensation. Upon detecting abnormal pH/UA levels, the polypyrrole-based drug carrier releases ciprofloxacin via 0.6 V electrical stimulation, successfully inhibiting bacterial growth in vitro. The array is assembled as a 3D patch, connected to a flexible printed circuit board, and embedded in a wound bandage, offering potential for remote wound monitoring, targeted treatment, and wireless wound management. |
| first_indexed | 2024-04-24T23:04:43Z |
| format | Article |
| id | doaj.art-4a953261510e4a088f1b41a43214b8d4 |
| institution | Directory Open Access Journal |
| issn | 2662-4443 |
| language | English |
| last_indexed | 2024-04-24T23:04:43Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Materials |
| spelling | doaj.art-4a953261510e4a088f1b41a43214b8d42024-03-17T12:33:02ZengNature PortfolioCommunications Materials2662-44432024-03-015111010.1038/s43246-024-00469-5A conducting polymer-based array with multiplex sensing and drug delivery capabilities for smart bandagesLingyin Meng0Sheng Liu1Baris Ata Borsa2Mats Eriksson3Wing Cheung Mak4Sensor and Actuator Systems, Department of Physics, Chemistry and Biology, Linköping UniversityCollege of Computer Science and Technology, Huaibei Normal UniversityNucleic Acid Technologies Lab, Department of Physics, Chemistry and Biology, Linköping UniversitySensor and Actuator Systems, Department of Physics, Chemistry and Biology, Linköping UniversityDepartment of Biomedical Engineering, The Chinese University of Hong KongAbstract Effective individual wound management, particularly in cases of prolonged healing and increased infection vulnerability, has prompted the development of wound theranostics, combining real-time diagnostic assessment and on-demand treatment. Here, we present a multifunctional conducting polymer-based smart theranostic bandage that integrates pH sensing, pH-compensated uric acid (UA) biosensing, and on-demand antibiotic release using different conducting polymers, each leveraging their advantageous intrinsic properties. Specifically, the polyaniline-based pH sensor operates reversibly across a pH range of 4–10, while the functionalized poly(3,4-ethylenedioxythiophene)-based UA biosensor exhibits a linear response up to 0.9 mM UA. Simultaneous detection of pH and UA allows accurate UA determination via pH compensation. Upon detecting abnormal pH/UA levels, the polypyrrole-based drug carrier releases ciprofloxacin via 0.6 V electrical stimulation, successfully inhibiting bacterial growth in vitro. The array is assembled as a 3D patch, connected to a flexible printed circuit board, and embedded in a wound bandage, offering potential for remote wound monitoring, targeted treatment, and wireless wound management.https://doi.org/10.1038/s43246-024-00469-5 |
| spellingShingle | Lingyin Meng Sheng Liu Baris Ata Borsa Mats Eriksson Wing Cheung Mak A conducting polymer-based array with multiplex sensing and drug delivery capabilities for smart bandages Communications Materials |
| title | A conducting polymer-based array with multiplex sensing and drug delivery capabilities for smart bandages |
| title_full | A conducting polymer-based array with multiplex sensing and drug delivery capabilities for smart bandages |
| title_fullStr | A conducting polymer-based array with multiplex sensing and drug delivery capabilities for smart bandages |
| title_full_unstemmed | A conducting polymer-based array with multiplex sensing and drug delivery capabilities for smart bandages |
| title_short | A conducting polymer-based array with multiplex sensing and drug delivery capabilities for smart bandages |
| title_sort | conducting polymer based array with multiplex sensing and drug delivery capabilities for smart bandages |
| url | https://doi.org/10.1038/s43246-024-00469-5 |
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