Slimmer or fertile? Pharmacological mechanisms involved in reduced sperm quality and fertility in rats exposed to the anorexigen sibutramine.

Slimmer or fertile? Pharmacological mechanisms involved in reduced sperm quality and fertility in rats exposed to the anorexigen sibutramine.

Sperm acquire motility and fertility capacity during epididymal transit, under the control of androgens and sympathetic innervations. It is already known that the acceleration of epididymal sperm transit time can lead to lower sperm quality. In a previous work we showed that rats exposed to the anor...

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Bibliographic Details
Main Authors: Cibele S Borges, Gabriela Missassi, Enio S A Pacini, Luiz Ricardo A Kiguti, Marciana Sanabria, Raquel F Silva, Thais P Banzato, Juliana E Perobelli, André S Pupo, Wilma G Kempinas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3680400?pdf=render

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