Non-invasive flow mapping of parasagittal meningeal lymphatics using 2D interslice flow saturation MRI
Abstract The clearance pathways of brain waste products in humans are still under debate in part due to the lack of noninvasive imaging techniques for meningeal lymphatic vessels (mLVs). In this study, we propose a new noninvasive mLVs imaging technique based on an inter-slice blood perfusion MRI ca...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | Fluids and Barriers of the CNS |
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| Online Access: | https://doi.org/10.1186/s12987-023-00446-z |
| _version_ | 1797817833269231616 |
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| author | Jun-Hee Kim Roh-Eul Yoo Seung Hong Choi Sung-Hong Park |
| author_facet | Jun-Hee Kim Roh-Eul Yoo Seung Hong Choi Sung-Hong Park |
| author_sort | Jun-Hee Kim |
| collection | DOAJ |
| description | Abstract The clearance pathways of brain waste products in humans are still under debate in part due to the lack of noninvasive imaging techniques for meningeal lymphatic vessels (mLVs). In this study, we propose a new noninvasive mLVs imaging technique based on an inter-slice blood perfusion MRI called alternate ascending/descending directional navigation (ALADDIN). ALADDIN with inversion recovery (IR) at single inversion time of 2300 ms (single-TI IR-ALADDIN) clearly demonstrated parasagittal mLVs around the human superior sagittal sinus (SSS) with better detectability and specificity than the previously suggested noninvasive imaging techniques. While in many studies it has been difficult to detect mLVs and confirm their signal source noninvasively, the detection of mLVs in this study was confirmed by their posterior to anterior flow direction and their velocities and morphological features, which were consistent with those from the literature. In addition, IR-ALADDIN was compared with contrast-enhanced black blood imaging to confirm the detection of mLVs and its similarity. For the quantification of flow velocity of mLVs, IR-ALADDIN was performed at three inversion times of 2000, 2300, and 2600 ms (three-TI IR-ALADDIN) for both a flow phantom and humans. For this preliminary result, the flow velocity of the dorsal mLVs in humans ranged between 2.2 and 2.7 mm/s. Overall, (i) the single-TI IR-ALADDIN can be used as a novel non-invasive method to visualize mLVs in the whole brain with scan time of ~ 17 min and (ii) the multi-TI IR-ALADDIN can be used as a way to quantify the flow velocity of mLVs with a scan time of ~ 10 min (or shorter) in a limited coverage. Accordingly, the suggested approach can be applied to noninvasively studying meningeal lymphatic flows in general and also understanding the clearance pathways of waste production through mLVs in humans, which warrants further investigation. |
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| format | Article |
| id | doaj.art-4a96682f38004babb1c79988fbffbc64 |
| institution | Directory Open Access Journal |
| issn | 2045-8118 |
| language | English |
| last_indexed | 2024-03-13T08:59:16Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Fluids and Barriers of the CNS |
| spelling | doaj.art-4a96682f38004babb1c79988fbffbc642023-05-28T11:25:23ZengBMCFluids and Barriers of the CNS2045-81182023-05-0120111410.1186/s12987-023-00446-zNon-invasive flow mapping of parasagittal meningeal lymphatics using 2D interslice flow saturation MRIJun-Hee Kim0Roh-Eul Yoo1Seung Hong Choi2Sung-Hong Park3Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)Department of Radiology, Seoul National University College of MedicineDepartment of Radiology, Seoul National University College of MedicineDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)Abstract The clearance pathways of brain waste products in humans are still under debate in part due to the lack of noninvasive imaging techniques for meningeal lymphatic vessels (mLVs). In this study, we propose a new noninvasive mLVs imaging technique based on an inter-slice blood perfusion MRI called alternate ascending/descending directional navigation (ALADDIN). ALADDIN with inversion recovery (IR) at single inversion time of 2300 ms (single-TI IR-ALADDIN) clearly demonstrated parasagittal mLVs around the human superior sagittal sinus (SSS) with better detectability and specificity than the previously suggested noninvasive imaging techniques. While in many studies it has been difficult to detect mLVs and confirm their signal source noninvasively, the detection of mLVs in this study was confirmed by their posterior to anterior flow direction and their velocities and morphological features, which were consistent with those from the literature. In addition, IR-ALADDIN was compared with contrast-enhanced black blood imaging to confirm the detection of mLVs and its similarity. For the quantification of flow velocity of mLVs, IR-ALADDIN was performed at three inversion times of 2000, 2300, and 2600 ms (three-TI IR-ALADDIN) for both a flow phantom and humans. For this preliminary result, the flow velocity of the dorsal mLVs in humans ranged between 2.2 and 2.7 mm/s. Overall, (i) the single-TI IR-ALADDIN can be used as a novel non-invasive method to visualize mLVs in the whole brain with scan time of ~ 17 min and (ii) the multi-TI IR-ALADDIN can be used as a way to quantify the flow velocity of mLVs with a scan time of ~ 10 min (or shorter) in a limited coverage. Accordingly, the suggested approach can be applied to noninvasively studying meningeal lymphatic flows in general and also understanding the clearance pathways of waste production through mLVs in humans, which warrants further investigation.https://doi.org/10.1186/s12987-023-00446-zMeningeal lymphatic vesselFlow velocityParasagittalMagnetic resonance imagingNon-invasivePerfusion imaging |
| spellingShingle | Jun-Hee Kim Roh-Eul Yoo Seung Hong Choi Sung-Hong Park Non-invasive flow mapping of parasagittal meningeal lymphatics using 2D interslice flow saturation MRI Fluids and Barriers of the CNS Meningeal lymphatic vessel Flow velocity Parasagittal Magnetic resonance imaging Non-invasive Perfusion imaging |
| title | Non-invasive flow mapping of parasagittal meningeal lymphatics using 2D interslice flow saturation MRI |
| title_full | Non-invasive flow mapping of parasagittal meningeal lymphatics using 2D interslice flow saturation MRI |
| title_fullStr | Non-invasive flow mapping of parasagittal meningeal lymphatics using 2D interslice flow saturation MRI |
| title_full_unstemmed | Non-invasive flow mapping of parasagittal meningeal lymphatics using 2D interslice flow saturation MRI |
| title_short | Non-invasive flow mapping of parasagittal meningeal lymphatics using 2D interslice flow saturation MRI |
| title_sort | non invasive flow mapping of parasagittal meningeal lymphatics using 2d interslice flow saturation mri |
| topic | Meningeal lymphatic vessel Flow velocity Parasagittal Magnetic resonance imaging Non-invasive Perfusion imaging |
| url | https://doi.org/10.1186/s12987-023-00446-z |
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