Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions
Formation of peritoneal adhesions (PA) is one of the major complications following intra-abdominal surgery. It is primarily caused by activation of the mesothelial layer and underlying tissues in the peritoneal membrane resulting in the transition of mesothelial cells (MCs) and fibroblasts to a pro-...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/1/45 |
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| author | Anna Kocurkova Kristina Nesporova Miriam Sandanusova Michaela Kerberova Katerina Lehka Vladimir Velebny Lukas Kubala Gabriela Ambrozova |
| author_facet | Anna Kocurkova Kristina Nesporova Miriam Sandanusova Michaela Kerberova Katerina Lehka Vladimir Velebny Lukas Kubala Gabriela Ambrozova |
| author_sort | Anna Kocurkova |
| collection | DOAJ |
| description | Formation of peritoneal adhesions (PA) is one of the major complications following intra-abdominal surgery. It is primarily caused by activation of the mesothelial layer and underlying tissues in the peritoneal membrane resulting in the transition of mesothelial cells (MCs) and fibroblasts to a pro-fibrotic phenotype. Pro-fibrotic transition of MCs—mesothelial-to-mesenchymal transition (MMT), and fibroblasts activation to myofibroblasts are interconnected to changes in cellular metabolism and culminate in the deposition of extracellular matrix (ECM) in the form of fibrotic tissue between injured sides in the abdominal cavity. However, ECM is not only a mechanical scaffold of the newly synthetized tissue but reciprocally affects fibrosis development. Hyaluronan (HA), an important component of ECM, is a non-sulfated glycosaminoglycan consisting of N-acetyl-D-glucosamine (GlcNAc) and D-glucuronic acid (GlcUA) that can affect the majority of processes involved in PA formation. This review considers the role of endogenously produced HA in the context of different fibrosis-related pathologies and its overlap in the development of PA. |
| first_indexed | 2024-03-10T01:50:54Z |
| format | Article |
| id | doaj.art-4a9c7092aded4b76b22a572d53d992ce |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T01:50:54Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-4a9c7092aded4b76b22a572d53d992ce2023-11-23T13:06:11ZengMDPI AGBiomolecules2218-273X2021-12-011214510.3390/biom12010045Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal AdhesionsAnna Kocurkova0Kristina Nesporova1Miriam Sandanusova2Michaela Kerberova3Katerina Lehka4Vladimir Velebny5Lukas Kubala6Gabriela Ambrozova7Institute of Biophysics, Academy of Sciences of the Czech Republic, 612 65 Brno, Czech RepublicContipro a.s., Dolní Dobrouč 401, 561 02 Dolní Dobrouč, Czech RepublicInstitute of Biophysics, Academy of Sciences of the Czech Republic, 612 65 Brno, Czech RepublicInstitute of Biophysics, Academy of Sciences of the Czech Republic, 612 65 Brno, Czech RepublicContipro a.s., Dolní Dobrouč 401, 561 02 Dolní Dobrouč, Czech RepublicContipro a.s., Dolní Dobrouč 401, 561 02 Dolní Dobrouč, Czech RepublicInstitute of Biophysics, Academy of Sciences of the Czech Republic, 612 65 Brno, Czech RepublicInstitute of Biophysics, Academy of Sciences of the Czech Republic, 612 65 Brno, Czech RepublicFormation of peritoneal adhesions (PA) is one of the major complications following intra-abdominal surgery. It is primarily caused by activation of the mesothelial layer and underlying tissues in the peritoneal membrane resulting in the transition of mesothelial cells (MCs) and fibroblasts to a pro-fibrotic phenotype. Pro-fibrotic transition of MCs—mesothelial-to-mesenchymal transition (MMT), and fibroblasts activation to myofibroblasts are interconnected to changes in cellular metabolism and culminate in the deposition of extracellular matrix (ECM) in the form of fibrotic tissue between injured sides in the abdominal cavity. However, ECM is not only a mechanical scaffold of the newly synthetized tissue but reciprocally affects fibrosis development. Hyaluronan (HA), an important component of ECM, is a non-sulfated glycosaminoglycan consisting of N-acetyl-D-glucosamine (GlcNAc) and D-glucuronic acid (GlcUA) that can affect the majority of processes involved in PA formation. This review considers the role of endogenously produced HA in the context of different fibrosis-related pathologies and its overlap in the development of PA.https://www.mdpi.com/2218-273X/12/1/45peritoneal adhesionfibrosishyaluronanmesothelial cellmetabolisminflammation |
| spellingShingle | Anna Kocurkova Kristina Nesporova Miriam Sandanusova Michaela Kerberova Katerina Lehka Vladimir Velebny Lukas Kubala Gabriela Ambrozova Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions Biomolecules peritoneal adhesion fibrosis hyaluronan mesothelial cell metabolism inflammation |
| title | Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions |
| title_full | Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions |
| title_fullStr | Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions |
| title_full_unstemmed | Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions |
| title_short | Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions |
| title_sort | endogenously produced hyaluronan and its potential to regulate the development of peritoneal adhesions |
| topic | peritoneal adhesion fibrosis hyaluronan mesothelial cell metabolism inflammation |
| url | https://www.mdpi.com/2218-273X/12/1/45 |
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