Downregulation of MYCN through PI3K inhibition in mouse models of pediatric neural cancer

Downregulation of MYCN through PI3K inhibition in mouse models of pediatric neural cancer

The MYCN proto-oncogene is associated with poor outcome across a broad range of pediatric tumors. While amplification of MYCN drives subsets of high risk neuroblastoma and medulloblastoma, dysregulation of MYCN in medulloblastoma (in the absence of amplification) also contributes to pathogenesis. Si...

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Bibliographic Details
Main Authors: Tene Aneka Cage, Yvan eChanthery, Louis eChesler, Matthew eGrimmer, Zachary eKnight, Kevan eShokat, William A Weiss, W. Clay Gustafson
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Oncology
Subjects:
Medulloblastoma
Neuroblastoma
Cancer
Cell signaling
pediatric
mTOR
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00111/full

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