Bioaccumulation, histopathological and apoptotic effects of waterborne cadmium in the intestine of crucian carp Carassius auratus gibelio
Cadmium (Cd) is a highly toxic, nonessential heavy metal that has been associated with a variety of toxicological effects in both humans and animals. The main objective of this research was to investigate bioaccumulation, intestinal apoptosis, and digestive dysfunction effects of waterborne cadmium...
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| Language: | English |
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Elsevier
2021-07-01
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| Series: | Aquaculture Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352513421000855 |
| _version_ | 1818618496825688064 |
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| author | Yingying Yu Binbin Tong Yang Liu Hua Liu Hui Yu |
| author_facet | Yingying Yu Binbin Tong Yang Liu Hua Liu Hui Yu |
| author_sort | Yingying Yu |
| collection | DOAJ |
| description | Cadmium (Cd) is a highly toxic, nonessential heavy metal that has been associated with a variety of toxicological effects in both humans and animals. The main objective of this research was to investigate bioaccumulation, intestinal apoptosis, and digestive dysfunction effects of waterborne cadmium in the intestine of crucian carp Carassius auratus gibelio. Fish were exposed to 0, 100, and 500 μg/L waterborne Cd for 4 weeks, and the results showed that Cd accumulation in the intestine was significantly increased as Cd concentration increased. The intestinal structure was severely damaged, including mucosal fold length decreased, the rough endoplasmic reticulum underwent marked swelling and indistinct, and the intestinal microvilli transformed or nearly disappeared. The activities of intestinal apoptosis enzymes (Caspases 3, Caspases 8, and Caspases 9) and apoptosis rate of enterocyte cells were significantly elevated in 500 μg/L waterborne Cd group, activities of digestive enzymes (amylase and protease) were significantly decreased by 500 μg/L waterborne Cd. Overall, our results demonstrated that waterborne Cd exposure could increase Cd bioaccumulation in the intestine and destroy the intestinal digestibility of crucian carp, which in turn led to the occurrence of cell apoptosis. |
| first_indexed | 2024-12-16T17:22:31Z |
| format | Article |
| id | doaj.art-4aa0c8e174254c8297c1f10ee71e2838 |
| institution | Directory Open Access Journal |
| issn | 2352-5134 |
| language | English |
| last_indexed | 2024-12-16T17:22:31Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aquaculture Reports |
| spelling | doaj.art-4aa0c8e174254c8297c1f10ee71e28382022-12-21T22:23:08ZengElsevierAquaculture Reports2352-51342021-07-0120100669Bioaccumulation, histopathological and apoptotic effects of waterborne cadmium in the intestine of crucian carp Carassius auratus gibelioYingying Yu0Binbin Tong1Yang Liu2Hua Liu3Hui Yu4Guangdong Key Laboratory of Animal Molecular Design and Precise Breeding, School of Life Science and Engineering, Foshan University, Foshan, Guangdong, 528225, ChinaGuangdong Key Laboratory of Animal Molecular Design and Precise Breeding, School of Life Science and Engineering, Foshan University, Foshan, Guangdong, 528225, ChinaGuangdong Key Laboratory of Animal Molecular Design and Precise Breeding, School of Life Science and Engineering, Foshan University, Foshan, Guangdong, 528225, ChinaGuangdong Key Laboratory of Animal Molecular Design and Precise Breeding, School of Life Science and Engineering, Foshan University, Foshan, Guangdong, 528225, ChinaCorresponding author.; Guangdong Key Laboratory of Animal Molecular Design and Precise Breeding, School of Life Science and Engineering, Foshan University, Foshan, Guangdong, 528225, ChinaCadmium (Cd) is a highly toxic, nonessential heavy metal that has been associated with a variety of toxicological effects in both humans and animals. The main objective of this research was to investigate bioaccumulation, intestinal apoptosis, and digestive dysfunction effects of waterborne cadmium in the intestine of crucian carp Carassius auratus gibelio. Fish were exposed to 0, 100, and 500 μg/L waterborne Cd for 4 weeks, and the results showed that Cd accumulation in the intestine was significantly increased as Cd concentration increased. The intestinal structure was severely damaged, including mucosal fold length decreased, the rough endoplasmic reticulum underwent marked swelling and indistinct, and the intestinal microvilli transformed or nearly disappeared. The activities of intestinal apoptosis enzymes (Caspases 3, Caspases 8, and Caspases 9) and apoptosis rate of enterocyte cells were significantly elevated in 500 μg/L waterborne Cd group, activities of digestive enzymes (amylase and protease) were significantly decreased by 500 μg/L waterborne Cd. Overall, our results demonstrated that waterborne Cd exposure could increase Cd bioaccumulation in the intestine and destroy the intestinal digestibility of crucian carp, which in turn led to the occurrence of cell apoptosis.http://www.sciencedirect.com/science/article/pii/S2352513421000855CdCarassius auratus gibelioHistopathological damageApoptosisDysfunction |
| spellingShingle | Yingying Yu Binbin Tong Yang Liu Hua Liu Hui Yu Bioaccumulation, histopathological and apoptotic effects of waterborne cadmium in the intestine of crucian carp Carassius auratus gibelio Aquaculture Reports Cd Carassius auratus gibelio Histopathological damage Apoptosis Dysfunction |
| title | Bioaccumulation, histopathological and apoptotic effects of waterborne cadmium in the intestine of crucian carp Carassius auratus gibelio |
| title_full | Bioaccumulation, histopathological and apoptotic effects of waterborne cadmium in the intestine of crucian carp Carassius auratus gibelio |
| title_fullStr | Bioaccumulation, histopathological and apoptotic effects of waterborne cadmium in the intestine of crucian carp Carassius auratus gibelio |
| title_full_unstemmed | Bioaccumulation, histopathological and apoptotic effects of waterborne cadmium in the intestine of crucian carp Carassius auratus gibelio |
| title_short | Bioaccumulation, histopathological and apoptotic effects of waterborne cadmium in the intestine of crucian carp Carassius auratus gibelio |
| title_sort | bioaccumulation histopathological and apoptotic effects of waterborne cadmium in the intestine of crucian carp carassius auratus gibelio |
| topic | Cd Carassius auratus gibelio Histopathological damage Apoptosis Dysfunction |
| url | http://www.sciencedirect.com/science/article/pii/S2352513421000855 |
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