Fibroblast growth factor signaling in axons: from development to disease
Abstract The fibroblast growth factor (FGF) family regulates various and important aspects of nervous system development, ranging from the well-established roles in neuronal patterning to more recent and exciting functions in axonal growth and synaptogenesis. In addition, FGFs play a critical role i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01284-0 |
| _version_ | 1797557687515348992 |
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| author | Diogo Tomé Marta S. Dias Joana Correia Ramiro D. Almeida |
| author_facet | Diogo Tomé Marta S. Dias Joana Correia Ramiro D. Almeida |
| author_sort | Diogo Tomé |
| collection | DOAJ |
| description | Abstract The fibroblast growth factor (FGF) family regulates various and important aspects of nervous system development, ranging from the well-established roles in neuronal patterning to more recent and exciting functions in axonal growth and synaptogenesis. In addition, FGFs play a critical role in axonal regeneration, particularly after spinal cord injury, confirming their versatile nature in the nervous system. Due to their widespread involvement in neural development, the FGF system also underlies several human neurological disorders. While particular attention has been given to FGFs in a whole-cell context, their effects at the axonal level are in most cases undervalued. Here we discuss the endeavor of the FGF system in axons, we delve into this neuronal subcompartment to provide an original view of this multipurpose family of growth factors in nervous system (dys)function. Video Abstract |
| first_indexed | 2024-03-10T17:20:10Z |
| format | Article |
| id | doaj.art-4aa0e29309464293ac34c6001bf39ff8 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-03-10T17:20:10Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-4aa0e29309464293ac34c6001bf39ff82023-11-20T10:22:02ZengBMCCell Communication and Signaling1478-811X2023-10-0121111910.1186/s12964-023-01284-0Fibroblast growth factor signaling in axons: from development to diseaseDiogo Tomé0Marta S. Dias1Joana Correia2Ramiro D. Almeida3Institute of Biomedicine, Department of Medical Sciences - iBiMED, University of AveiroInstitute of Biomedicine, Department of Medical Sciences - iBiMED, University of AveiroInstitute of Biomedicine, Department of Medical Sciences - iBiMED, University of AveiroInstitute of Biomedicine, Department of Medical Sciences - iBiMED, University of AveiroAbstract The fibroblast growth factor (FGF) family regulates various and important aspects of nervous system development, ranging from the well-established roles in neuronal patterning to more recent and exciting functions in axonal growth and synaptogenesis. In addition, FGFs play a critical role in axonal regeneration, particularly after spinal cord injury, confirming their versatile nature in the nervous system. Due to their widespread involvement in neural development, the FGF system also underlies several human neurological disorders. While particular attention has been given to FGFs in a whole-cell context, their effects at the axonal level are in most cases undervalued. Here we discuss the endeavor of the FGF system in axons, we delve into this neuronal subcompartment to provide an original view of this multipurpose family of growth factors in nervous system (dys)function. Video Abstracthttps://doi.org/10.1186/s12964-023-01284-0FGFSignaling pathwaysAxonsPresynaptic terminalAxonal injuryNeuronal disorders |
| spellingShingle | Diogo Tomé Marta S. Dias Joana Correia Ramiro D. Almeida Fibroblast growth factor signaling in axons: from development to disease Cell Communication and Signaling FGF Signaling pathways Axons Presynaptic terminal Axonal injury Neuronal disorders |
| title | Fibroblast growth factor signaling in axons: from development to disease |
| title_full | Fibroblast growth factor signaling in axons: from development to disease |
| title_fullStr | Fibroblast growth factor signaling in axons: from development to disease |
| title_full_unstemmed | Fibroblast growth factor signaling in axons: from development to disease |
| title_short | Fibroblast growth factor signaling in axons: from development to disease |
| title_sort | fibroblast growth factor signaling in axons from development to disease |
| topic | FGF Signaling pathways Axons Presynaptic terminal Axonal injury Neuronal disorders |
| url | https://doi.org/10.1186/s12964-023-01284-0 |
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