Serum calcitonin gene related peptide (CGRP) levels in migraine: A study on its clinical correlation and diagnostic efficacy
Migraine is a primary headache disorder marked by recurrent unilateral headache episodes. Calcitonin gene related peptide (CGRP) plays major role in migraine pathophysiology. CGRP is multifunctional, and its vasodilating activity within the central and peripheral blood vessels is one in all its prim...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2021-09-01
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| Series: | Romanian Journal of Neurology |
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| Online Access: | https://rjn.com.ro/articles/2021.3/RJN_2021_3_Art-13.pdf |
| _version_ | 1817986672658219008 |
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| author | Sofia Khatoon Noorunissa Begum Hafeeza Sultana Maryam Rashed Mohammed Zoheb Aleem Ahmed Khan Sara Shreen Syed Iqbal Ahmed |
| author_facet | Sofia Khatoon Noorunissa Begum Hafeeza Sultana Maryam Rashed Mohammed Zoheb Aleem Ahmed Khan Sara Shreen Syed Iqbal Ahmed |
| author_sort | Sofia Khatoon |
| collection | DOAJ |
| description | Migraine is a primary headache disorder marked by recurrent unilateral headache episodes. Calcitonin gene related peptide (CGRP) plays major role in migraine pathophysiology. CGRP is multifunctional, and its vasodilating activity within the central and peripheral blood vessels is one in all its primary functions. The intention is to prove serum calcitonin gene related peptide (CGRP) as an early diagnostic tool for migraine and the novelty is to correlate it with characteristics of migraine so that it helps in early initiation of treatment.
Methods. 100 subjects including 90 patients with migraine and 10 with non-headache (NH) age-matched controls were prospectively recruited in our current study. The subjects were aged from 15- 50 years. The clinical assessment was made every month for the three months after the start of therapy. The subjects were compared based on the serum CGRP values. Serum CGRP concentrations were measured by using CGRP ELISA kit.
Results. Out of total subjects selected, the maximum (23.3%) subjects were between age 26 and 30 years and least effected age group was 46-50 years (4.44%). Females’ predominance with 82% than males with 18%. Stress was major trigger occurring in 57% of cases. Throbbing pain with elevated CGRP levels 130.44±114.22 and p value (p = 0.01). The average CGRP levels was higher in test group 149.00±93.86 compared to control 61.30±24.37 with p value (p = 0.02).
Conclusions. The serum CGRP levels were statistically more in migraine patients correlated with characteristics like throbbing type of pain, stress and inadequate sleep. Hence, the serum CGRP levels estimation can be considered as a diagnostic tool for migraine when the clinical character’s over lap or early in the course of migraine when all criteria for diagnosis are not yet fulfilled. |
| first_indexed | 2024-04-14T00:12:15Z |
| format | Article |
| id | doaj.art-4aa1dac1e9ab40fda2b8289e95269d03 |
| institution | Directory Open Access Journal |
| issn | 1843-8148 2069-6094 |
| language | English |
| last_indexed | 2024-04-14T00:12:15Z |
| publishDate | 2021-09-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Neurology |
| spelling | doaj.art-4aa1dac1e9ab40fda2b8289e95269d032022-12-22T02:23:17ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942021-09-0120334234810.37897/RJN.2021.3.13Serum calcitonin gene related peptide (CGRP) levels in migraine: A study on its clinical correlation and diagnostic efficacySofia Khatoon0Noorunissa Begum1Hafeeza Sultana2Maryam Rashed3Mohammed Zoheb4Aleem Ahmed Khan5Sara Shreen6Syed Iqbal Ahmed7Department of Pharmacy Practice, Deccan School of Pharmacy, Hyderabad, IndiDepartment of Pharmacy Practice, Deccan School of Pharmacy, Hyderabad, IndiDepartment of Pharmacy Practice, Deccan School of Pharmacy, Hyderabad, IndiaDepartment of Pharmacy Practice, Deccan School of Pharmacy, Hyderabad, IndiaDepartment of Neurology, Owaisi Hospital and Research Center, Deccan College of Medical Sciences, Hyderabad, IndiaCentral Research lab, Center for Liver Research and Diagnostics, Deccan College of Medical Sciences, Hyderabad, IndiaDepartment of Pharmacy practice, Deccan School of Pharmacy, Hyderabad, IndiaDepartment of Pharmacy practice, Deccan School of Pharmacy, Hyderabad, IndiaMigraine is a primary headache disorder marked by recurrent unilateral headache episodes. Calcitonin gene related peptide (CGRP) plays major role in migraine pathophysiology. CGRP is multifunctional, and its vasodilating activity within the central and peripheral blood vessels is one in all its primary functions. The intention is to prove serum calcitonin gene related peptide (CGRP) as an early diagnostic tool for migraine and the novelty is to correlate it with characteristics of migraine so that it helps in early initiation of treatment. Methods. 100 subjects including 90 patients with migraine and 10 with non-headache (NH) age-matched controls were prospectively recruited in our current study. The subjects were aged from 15- 50 years. The clinical assessment was made every month for the three months after the start of therapy. The subjects were compared based on the serum CGRP values. Serum CGRP concentrations were measured by using CGRP ELISA kit. Results. Out of total subjects selected, the maximum (23.3%) subjects were between age 26 and 30 years and least effected age group was 46-50 years (4.44%). Females’ predominance with 82% than males with 18%. Stress was major trigger occurring in 57% of cases. Throbbing pain with elevated CGRP levels 130.44±114.22 and p value (p = 0.01). The average CGRP levels was higher in test group 149.00±93.86 compared to control 61.30±24.37 with p value (p = 0.02). Conclusions. The serum CGRP levels were statistically more in migraine patients correlated with characteristics like throbbing type of pain, stress and inadequate sleep. Hence, the serum CGRP levels estimation can be considered as a diagnostic tool for migraine when the clinical character’s over lap or early in the course of migraine when all criteria for diagnosis are not yet fulfilled.https://rjn.com.ro/articles/2021.3/RJN_2021_3_Art-13.pdfmigrainecgrpneuralgiaichdphotophobiaphonophobiaelisa |
| spellingShingle | Sofia Khatoon Noorunissa Begum Hafeeza Sultana Maryam Rashed Mohammed Zoheb Aleem Ahmed Khan Sara Shreen Syed Iqbal Ahmed Serum calcitonin gene related peptide (CGRP) levels in migraine: A study on its clinical correlation and diagnostic efficacy Romanian Journal of Neurology migraine cgrp neuralgia ichd photophobia phonophobia elisa |
| title | Serum calcitonin gene related peptide (CGRP) levels in migraine: A study on its clinical correlation and diagnostic efficacy |
| title_full | Serum calcitonin gene related peptide (CGRP) levels in migraine: A study on its clinical correlation and diagnostic efficacy |
| title_fullStr | Serum calcitonin gene related peptide (CGRP) levels in migraine: A study on its clinical correlation and diagnostic efficacy |
| title_full_unstemmed | Serum calcitonin gene related peptide (CGRP) levels in migraine: A study on its clinical correlation and diagnostic efficacy |
| title_short | Serum calcitonin gene related peptide (CGRP) levels in migraine: A study on its clinical correlation and diagnostic efficacy |
| title_sort | serum calcitonin gene related peptide cgrp levels in migraine a study on its clinical correlation and diagnostic efficacy |
| topic | migraine cgrp neuralgia ichd photophobia phonophobia elisa |
| url | https://rjn.com.ro/articles/2021.3/RJN_2021_3_Art-13.pdf |
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