Ectopic pregnancy treatment by combination therapy
Detectability of early stages of ectopic pregnancies has increased due to improvements in ultrasonographic and biochemical techniques. Since the patients’ future procreative plans must be taken into consideration when commencing treatment, the goal of this work was to compare the effects of treatmen...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2016-01-01
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| Series: | Open Medicine |
| Subjects: | |
| Online Access: | http://www.degruyter.com/view/j/med.2016.11.issue-1/med-2016-0091/med-2016-0091.xml?format=INT |
| _version_ | 1818357876704411648 |
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| author | Cymbaluk-Płoska Aneta Chudecka-Głaz Anita Kuźniak Sławomir Menkiszak Janusz |
| author_facet | Cymbaluk-Płoska Aneta Chudecka-Głaz Anita Kuźniak Sławomir Menkiszak Janusz |
| author_sort | Cymbaluk-Płoska Aneta |
| collection | DOAJ |
| description | Detectability of early stages of ectopic pregnancies has increased due to improvements in ultrasonographic and biochemical techniques. Since the patients’ future procreative plans must be taken into consideration when commencing treatment, the goal of this work was to compare the effects of treatment methods and their impact on fertility. The study included 91 patients treated surgically for ectopic pregnancy. The choice of treatment depended on patients’ general condition, ultrasonographic evaluation and serum level of beta-hCG. A combination of laparoscopic and conservative systemic treatment was applied in 70% of cases. More rapid beta-hCG reduction was noted when laparoscopy and intra-oviductal injection of hyperosmolar glucose or methotrexate (MTX) were combined with intramuscular administration of MTX at a dose of 50 mg/m2. Follow-up examination of 66 patients revealed that the greatest number of spontaneous pregnancies (48%) resulted after this combination therapy. We conclude that this combination treatment is safe and provides satisfactory results in terms of future fertility. |
| first_indexed | 2024-12-13T20:20:05Z |
| format | Article |
| id | doaj.art-4aa37071e5e740a69b2aa6ec739b3b9f |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-12-13T20:20:05Z |
| publishDate | 2016-01-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-4aa37071e5e740a69b2aa6ec739b3b9f2022-12-21T23:32:43ZengDe GruyterOpen Medicine2391-54632016-01-0111153053610.1515/med-2016-0091med-2016-0091Ectopic pregnancy treatment by combination therapyCymbaluk-Płoska Aneta0Chudecka-Głaz Anita1Kuźniak Sławomir2Menkiszak Janusz3Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, PolandDepartment of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, PolandDepartment of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, PolandDetectability of early stages of ectopic pregnancies has increased due to improvements in ultrasonographic and biochemical techniques. Since the patients’ future procreative plans must be taken into consideration when commencing treatment, the goal of this work was to compare the effects of treatment methods and their impact on fertility. The study included 91 patients treated surgically for ectopic pregnancy. The choice of treatment depended on patients’ general condition, ultrasonographic evaluation and serum level of beta-hCG. A combination of laparoscopic and conservative systemic treatment was applied in 70% of cases. More rapid beta-hCG reduction was noted when laparoscopy and intra-oviductal injection of hyperosmolar glucose or methotrexate (MTX) were combined with intramuscular administration of MTX at a dose of 50 mg/m2. Follow-up examination of 66 patients revealed that the greatest number of spontaneous pregnancies (48%) resulted after this combination therapy. We conclude that this combination treatment is safe and provides satisfactory results in terms of future fertility.http://www.degruyter.com/view/j/med.2016.11.issue-1/med-2016-0091/med-2016-0091.xml?format=INTEctopic pregnancyLaparoscopyHyperosmolar glucoseMethotrexate injection |
| spellingShingle | Cymbaluk-Płoska Aneta Chudecka-Głaz Anita Kuźniak Sławomir Menkiszak Janusz Ectopic pregnancy treatment by combination therapy Open Medicine Ectopic pregnancy Laparoscopy Hyperosmolar glucose Methotrexate injection |
| title | Ectopic pregnancy treatment by combination therapy |
| title_full | Ectopic pregnancy treatment by combination therapy |
| title_fullStr | Ectopic pregnancy treatment by combination therapy |
| title_full_unstemmed | Ectopic pregnancy treatment by combination therapy |
| title_short | Ectopic pregnancy treatment by combination therapy |
| title_sort | ectopic pregnancy treatment by combination therapy |
| topic | Ectopic pregnancy Laparoscopy Hyperosmolar glucose Methotrexate injection |
| url | http://www.degruyter.com/view/j/med.2016.11.issue-1/med-2016-0091/med-2016-0091.xml?format=INT |
| work_keys_str_mv | AT cymbalukpłoskaaneta ectopicpregnancytreatmentbycombinationtherapy AT chudeckagłazanita ectopicpregnancytreatmentbycombinationtherapy AT kuzniaksławomir ectopicpregnancytreatmentbycombinationtherapy AT menkiszakjanusz ectopicpregnancytreatmentbycombinationtherapy |