MTEP, a Selective mGluR5 Antagonist, Had a Neuroprotective Effect but Did Not Prevent the Development of Spontaneous Recurrent Seizures and Behavioral Comorbidities in the Rat Lithium–Pilocarpine Model of Epilepsy

MTEP, a Selective mGluR5 Antagonist, Had a Neuroprotective Effect but Did Not Prevent the Development of Spontaneous Recurrent Seizures and Behavioral Comorbidities in the Rat Lithium–Pilocarpine Model of Epilepsy

Metabotropic glutamate receptors (mGluRs) are expressed predominantly on neurons and glial cells and are involved in the modulation of a wide range of signal transduction cascades. Therefore, different subtypes of mGluRs are considered a promising target for the treatment of various brain diseases....

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Bibliographic Details
Main Authors: Alexandra V. Dyomina, Anna A. Kovalenko, Maria V. Zakharova, Tatiana Yu. Postnikova, Alexandra V. Griflyuk, Ilya V. Smolensky, Irina V. Antonova, Aleksey V. Zaitsev
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
temporal lobe epilepsy
excitatory amino acid transporter 2
glial fibrillary acidic protein
open field test
novel object recognition test
hippocampus
Online Access:https://www.mdpi.com/1422-0067/23/1/497

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