CCR5 is a novel target for the treatment of experimental alopecia areata

CCR5 is a novel target for the treatment of experimental alopecia areata

Abstract Background Alopecia areata (AA) is an organ‐specific and cell‐mediated autoimmune disease. Hair follicle autoantigens are disclosed to these autoreactive NKG2D+CD8+ T cells. A Th1 chemokine, CXCL10, is highly expressed on hair follicle keratinocytes and leads to the infiltration of CXCR3+ a...

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Bibliographic Details
Main Authors: Taisuke Ito, Takahiro Suzuki, Atsuko Funakoshi, Toshiharu Fujiyama, Yoshiki Tokura
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Journal of Cutaneous Immunology and Allergy
Subjects:
alopecia areata
CCR5
chemotaxis
maraviroc
RANTES
Online Access:https://doi.org/10.1002/cia2.12092

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