Size Limit and Energy Analysis of Nanoparticles during Wrapping Process by Membrane
The wrapping of nanoparticles (NPs) by a membrane is a phenomenon of widespread and generic interest in biology, as well as in a variety of technological applications, such as drug delivery, clinical diagnostics, and biomedical imaging. However, the mechanisms of the interaction between the membrane...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-11-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/8/11/899 |
| _version_ | 1818249489038704640 |
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| author | Xinpei Meng Xinlei Li |
| author_facet | Xinpei Meng Xinlei Li |
| author_sort | Xinpei Meng |
| collection | DOAJ |
| description | The wrapping of nanoparticles (NPs) by a membrane is a phenomenon of widespread and generic interest in biology, as well as in a variety of technological applications, such as drug delivery, clinical diagnostics, and biomedical imaging. However, the mechanisms of the interaction between the membrane and NPs are not well understood yet. In this paper, we have presented an analytic thermodynamic model to investigate the wrapping process of NPs by a cell membrane. It is found that the bending energy of the deformed membrane increases nonlinearly with increasing wrapping degree, which leads to a free energy barrier for the wrapping. On the basis of analysis results, the wrapping of NPs can be divided into three types, i.e., impossible wrapping, barrier wrapping, and free wrapping. Furthermore, a phase diagram for the wrapping of NPs has been constructed, which clarifies the interrelated effects of the size and the ligand density of NPs. We hope that this work can provide some help in understanding the physical mechanism of the wrapping of NPs. |
| first_indexed | 2024-12-12T15:37:18Z |
| format | Article |
| id | doaj.art-4aa4a6a20940489691022e0a57b7a2b5 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-12-12T15:37:18Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-4aa4a6a20940489691022e0a57b7a2b52022-12-22T00:19:58ZengMDPI AGNanomaterials2079-49912018-11-0181189910.3390/nano8110899nano8110899Size Limit and Energy Analysis of Nanoparticles during Wrapping Process by MembraneXinpei Meng0Xinlei Li1Mechatronics Technology R&D and Service Center, Dongguan Polytechnic, Dongguan 523808, ChinaMOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, ChinaThe wrapping of nanoparticles (NPs) by a membrane is a phenomenon of widespread and generic interest in biology, as well as in a variety of technological applications, such as drug delivery, clinical diagnostics, and biomedical imaging. However, the mechanisms of the interaction between the membrane and NPs are not well understood yet. In this paper, we have presented an analytic thermodynamic model to investigate the wrapping process of NPs by a cell membrane. It is found that the bending energy of the deformed membrane increases nonlinearly with increasing wrapping degree, which leads to a free energy barrier for the wrapping. On the basis of analysis results, the wrapping of NPs can be divided into three types, i.e., impossible wrapping, barrier wrapping, and free wrapping. Furthermore, a phase diagram for the wrapping of NPs has been constructed, which clarifies the interrelated effects of the size and the ligand density of NPs. We hope that this work can provide some help in understanding the physical mechanism of the wrapping of NPs.https://www.mdpi.com/2079-4991/8/11/899wrapping processendocytosisnanoparticlethermodynamicscell membrane |
| spellingShingle | Xinpei Meng Xinlei Li Size Limit and Energy Analysis of Nanoparticles during Wrapping Process by Membrane Nanomaterials wrapping process endocytosis nanoparticle thermodynamics cell membrane |
| title | Size Limit and Energy Analysis of Nanoparticles during Wrapping Process by Membrane |
| title_full | Size Limit and Energy Analysis of Nanoparticles during Wrapping Process by Membrane |
| title_fullStr | Size Limit and Energy Analysis of Nanoparticles during Wrapping Process by Membrane |
| title_full_unstemmed | Size Limit and Energy Analysis of Nanoparticles during Wrapping Process by Membrane |
| title_short | Size Limit and Energy Analysis of Nanoparticles during Wrapping Process by Membrane |
| title_sort | size limit and energy analysis of nanoparticles during wrapping process by membrane |
| topic | wrapping process endocytosis nanoparticle thermodynamics cell membrane |
| url | https://www.mdpi.com/2079-4991/8/11/899 |
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