Bcl-x short-isoform is essential for maintaining homeostasis of multiple tissues

Bcl-x short-isoform is essential for maintaining homeostasis of multiple tissues

Summary: BCL-2-like protein 1 (BCL2L1) is a key component of cell survival and death mechanisms. Its dysregulation and altered ratio of splicing variants associate with pathologies. However, isoform-specific loss-of-function analysis of BCL2L1 remains unexplored. Here we show the functional impact o...

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Bibliographic Details
Main Authors: Mariko Aoyagi Keller, Chun-yang Huang, Andreas Ivessa, Sukhwinder Singh, Peter J. Romanienko, Michinari Nakamura
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:iScience
Subjects:
Cardiovascular medicine
Cell biology
Developmental biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223004868

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