Allosteric Modulation of GPCRs of Class A by Cholesterol

Allosteric Modulation of GPCRs of Class A by Cholesterol

G-protein coupled receptors (GPCRs) are membrane proteins that convey extracellular signals to the cellular milieu. They represent a target for more than 30% of currently marketed drugs. Here we review the effects of membrane cholesterol on the function of GPCRs of Class A. We review both the specif...

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Bibliographic Details
Main Authors: Jan Jakubík, Esam E. El-Fakahany
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
GPCRs
cholesterol
allosteric modulation
Online Access:https://www.mdpi.com/1422-0067/22/4/1953

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