The Remarkable Genetics of Helicobacter pylori
ABSTRACT The Helicobacter pylori genome is more thoroughly mixed by homologous recombination than by any other organism that has been investigated, leading to apparent “free recombination” within populations. A recent mBio article by F. Ailloud, I. Estibariz, G. Pfaffinger, and S. Suerbaum (mBio 13:...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2022-12-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mbio.02158-22 |
| _version_ | 1811196261974409216 |
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| author | Daniel Falush |
| author_facet | Daniel Falush |
| author_sort | Daniel Falush |
| collection | DOAJ |
| description | ABSTRACT The Helicobacter pylori genome is more thoroughly mixed by homologous recombination than by any other organism that has been investigated, leading to apparent “free recombination” within populations. A recent mBio article by F. Ailloud, I. Estibariz, G. Pfaffinger, and S. Suerbaum (mBio 13:e01811-22, 2022, https://doi.org/10.1128/mbio.01811-22) helps to elucidate the cellular machinery that is used to achieve these unusual rates of genetic exchange. Specifically, they show that the UvrC gene, which is part of the repair machinery for DNA damage caused by ultraviolet light, has evolved an additional function in H. pylori, allowing very short tracts of DNA—with a mean length of only 28 bp—to be imported into the genome during natural transformation. |
| first_indexed | 2024-04-12T00:55:41Z |
| format | Article |
| id | doaj.art-4aa6ae1d51614dfb9279ca22caa588bb |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-04-12T00:55:41Z |
| publishDate | 2022-12-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-4aa6ae1d51614dfb9279ca22caa588bb2022-12-22T03:54:37ZengAmerican Society for MicrobiologymBio2150-75112022-12-0113610.1128/mbio.02158-22The Remarkable Genetics of Helicobacter pyloriDaniel Falush0The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People’s Republic of ChinaABSTRACT The Helicobacter pylori genome is more thoroughly mixed by homologous recombination than by any other organism that has been investigated, leading to apparent “free recombination” within populations. A recent mBio article by F. Ailloud, I. Estibariz, G. Pfaffinger, and S. Suerbaum (mBio 13:e01811-22, 2022, https://doi.org/10.1128/mbio.01811-22) helps to elucidate the cellular machinery that is used to achieve these unusual rates of genetic exchange. Specifically, they show that the UvrC gene, which is part of the repair machinery for DNA damage caused by ultraviolet light, has evolved an additional function in H. pylori, allowing very short tracts of DNA—with a mean length of only 28 bp—to be imported into the genome during natural transformation.https://journals.asm.org/doi/10.1128/mbio.02158-22Helicobacter pylorilinkage disequilibriumhomologous recombination |
| spellingShingle | Daniel Falush The Remarkable Genetics of Helicobacter pylori mBio Helicobacter pylori linkage disequilibrium homologous recombination |
| title | The Remarkable Genetics of Helicobacter pylori |
| title_full | The Remarkable Genetics of Helicobacter pylori |
| title_fullStr | The Remarkable Genetics of Helicobacter pylori |
| title_full_unstemmed | The Remarkable Genetics of Helicobacter pylori |
| title_short | The Remarkable Genetics of Helicobacter pylori |
| title_sort | remarkable genetics of helicobacter pylori |
| topic | Helicobacter pylori linkage disequilibrium homologous recombination |
| url | https://journals.asm.org/doi/10.1128/mbio.02158-22 |
| work_keys_str_mv | AT danielfalush theremarkablegeneticsofhelicobacterpylori AT danielfalush remarkablegeneticsofhelicobacterpylori |