Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel

Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel

Desensitization in pentameric ligand-gated ion channels plays an important role in regulating neuronal excitability. Here, we show that docosahexaenoic acid (DHA), a key ω−3 polyunsaturated fatty acid in synaptic membranes, enhances the agonist-induced transition to the desensitized state in the pro...

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Bibliographic Details
Main Authors: Sandip Basak, Nicolaus Schmandt, Yvonne Gicheru, Sudha Chakrapani
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
Cys-loop receptors
allosteric modulation
nanodiscs
site-directed spin labeling
Online Access:https://elifesciences.org/articles/23886

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