Spatiotemporal Regulation of Signaling: Focus on T Cell Activation and the Immunological Synapse
In a signaling network, not only the functions of molecules are important but when (temporal) and where (spatial) those functions are exerted and orchestrated is what defines the signaling output. To temporally and spatially modulate signaling events, cells generate specialized functional domains wi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/9/3283 |
| _version_ | 1797568670564614144 |
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| author | Esther Garcia Shehab Ismail |
| author_facet | Esther Garcia Shehab Ismail |
| author_sort | Esther Garcia |
| collection | DOAJ |
| description | In a signaling network, not only the functions of molecules are important but when (temporal) and where (spatial) those functions are exerted and orchestrated is what defines the signaling output. To temporally and spatially modulate signaling events, cells generate specialized functional domains with variable lifetime and size that concentrate signaling molecules, enhancing their transduction potential. The plasma membrane is a key in this regulation, as it constitutes a primary signaling hub that integrates signals within and across the membrane. Here, we examine some of the mechanisms that cells exhibit to spatiotemporally regulate signal transduction, focusing on the early events of T cell activation from triggering of T cell receptor to formation and maturation of the immunological synapse. |
| first_indexed | 2024-03-10T20:00:12Z |
| format | Article |
| id | doaj.art-4aa97d04590c4d77b78684288df84036 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:00:12Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4aa97d04590c4d77b78684288df840362023-11-19T23:37:46ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-01219328310.3390/ijms21093283Spatiotemporal Regulation of Signaling: Focus on T Cell Activation and the Immunological SynapseEsther Garcia0Shehab Ismail1CR-UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UKCR-UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UKIn a signaling network, not only the functions of molecules are important but when (temporal) and where (spatial) those functions are exerted and orchestrated is what defines the signaling output. To temporally and spatially modulate signaling events, cells generate specialized functional domains with variable lifetime and size that concentrate signaling molecules, enhancing their transduction potential. The plasma membrane is a key in this regulation, as it constitutes a primary signaling hub that integrates signals within and across the membrane. Here, we examine some of the mechanisms that cells exhibit to spatiotemporally regulate signal transduction, focusing on the early events of T cell activation from triggering of T cell receptor to formation and maturation of the immunological synapse.https://www.mdpi.com/1422-0067/21/9/3283signal transductionT cellsimmunological synapsemembrane domainsdiffusion barriers |
| spellingShingle | Esther Garcia Shehab Ismail Spatiotemporal Regulation of Signaling: Focus on T Cell Activation and the Immunological Synapse International Journal of Molecular Sciences signal transduction T cells immunological synapse membrane domains diffusion barriers |
| title | Spatiotemporal Regulation of Signaling: Focus on T Cell Activation and the Immunological Synapse |
| title_full | Spatiotemporal Regulation of Signaling: Focus on T Cell Activation and the Immunological Synapse |
| title_fullStr | Spatiotemporal Regulation of Signaling: Focus on T Cell Activation and the Immunological Synapse |
| title_full_unstemmed | Spatiotemporal Regulation of Signaling: Focus on T Cell Activation and the Immunological Synapse |
| title_short | Spatiotemporal Regulation of Signaling: Focus on T Cell Activation and the Immunological Synapse |
| title_sort | spatiotemporal regulation of signaling focus on t cell activation and the immunological synapse |
| topic | signal transduction T cells immunological synapse membrane domains diffusion barriers |
| url | https://www.mdpi.com/1422-0067/21/9/3283 |
| work_keys_str_mv | AT esthergarcia spatiotemporalregulationofsignalingfocusontcellactivationandtheimmunologicalsynapse AT shehabismail spatiotemporalregulationofsignalingfocusontcellactivationandtheimmunologicalsynapse |