Effect of Long-Term Oxygen Therapy on Reducing Rehospitalization of Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis
Abstract Introduction The aim of this work is to evaluate whether the addition of home oxygen therapy (HOT) would reduce readmission in chronic obstructive pulmonary disease (COPD) patients. Methods PubMed, ScopeMed, Cochrane, Scopus, and Google Scholar databases were searched. The search strategy u...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2023-04-01
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| Series: | Pulmonary Therapy |
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| Online Access: | https://doi.org/10.1007/s41030-023-00221-3 |
| _version_ | 1797817833493626880 |
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| author | Ramin Sami Mahsa Akafzadeh Savari Marjan Mansourian Roghayeh Ghazavi Rokhsareh Meamar |
| author_facet | Ramin Sami Mahsa Akafzadeh Savari Marjan Mansourian Roghayeh Ghazavi Rokhsareh Meamar |
| author_sort | Ramin Sami |
| collection | DOAJ |
| description | Abstract Introduction The aim of this work is to evaluate whether the addition of home oxygen therapy (HOT) would reduce readmission in chronic obstructive pulmonary disease (COPD) patients. Methods PubMed, ScopeMed, Cochrane, Scopus, and Google Scholar databases were searched. The search strategy used the following keywords “chronic obstructive pulmonary disease”, the intervention “long-term oxygen therapy”, and the outcome “readmission” combined with the AND operator. The Newcastle–Ottawa Scale and Jadad Scale were used for assessing the quality of cohort studies and clinical trials, respectively. A random-effects model was employed in this study after calculating the standard errors by 95% confidence intervals. The I2 statistic and Cochran’s Q-test were used to measure heterogeneity. To address heterogeneity, subgroup analyses were carried out according to the length of LTOT, which was classified as “over 8 months” and “under 8 months”. Results Seven studies were included in the analysis. In the pooled analysis, the RR [CI95%, p value], heterogeneity criteria for readmission reduced by 1.542 [1.284–1.851, < 0.001], I 2 = 60%, and 1.693 [1.645–1.744, < 0.001], I 2 = 60% for patients with a length of LTOT treatment under and above 8 months, respectively. A sensitivity analysis was conducted by systematically omitting each study, and it showed no influential studies. Egger’s test indicated no publication bias (p = 0.64). Conclusions Based on our results in this systematic review, long-tern oxygen therapy (LTOT) at home was associated with a significantly lower risk ratio of hospital readmission. However, the sample sizes in the studies necessitate larger RCTs to evaluate the effect of LTOT on readmission in COPD patients. |
| first_indexed | 2024-03-13T08:59:16Z |
| format | Article |
| id | doaj.art-4aa99f25412e4f5ca93eb2ad599893e3 |
| institution | Directory Open Access Journal |
| issn | 2364-1754 2364-1746 |
| language | English |
| last_indexed | 2024-03-13T08:59:16Z |
| publishDate | 2023-04-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Pulmonary Therapy |
| spelling | doaj.art-4aa99f25412e4f5ca93eb2ad599893e32023-05-28T11:24:06ZengAdis, Springer HealthcarePulmonary Therapy2364-17542364-17462023-04-019225527010.1007/s41030-023-00221-3Effect of Long-Term Oxygen Therapy on Reducing Rehospitalization of Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-AnalysisRamin Sami0Mahsa Akafzadeh Savari1Marjan Mansourian2Roghayeh Ghazavi3Rokhsareh Meamar4Department of Internal Medicine, School of Medicine, Isfahan University of Medical SciencesIsfahan Clinical Toxicology Research Center, Isfahan University of Medical SciencesDepartment of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical SciencesDepartment of Knowledge and Information Sciences, Faculty of Education and Psychology, Shahid Chamran University of AhvazIsfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Khorshid HospitalAbstract Introduction The aim of this work is to evaluate whether the addition of home oxygen therapy (HOT) would reduce readmission in chronic obstructive pulmonary disease (COPD) patients. Methods PubMed, ScopeMed, Cochrane, Scopus, and Google Scholar databases were searched. The search strategy used the following keywords “chronic obstructive pulmonary disease”, the intervention “long-term oxygen therapy”, and the outcome “readmission” combined with the AND operator. The Newcastle–Ottawa Scale and Jadad Scale were used for assessing the quality of cohort studies and clinical trials, respectively. A random-effects model was employed in this study after calculating the standard errors by 95% confidence intervals. The I2 statistic and Cochran’s Q-test were used to measure heterogeneity. To address heterogeneity, subgroup analyses were carried out according to the length of LTOT, which was classified as “over 8 months” and “under 8 months”. Results Seven studies were included in the analysis. In the pooled analysis, the RR [CI95%, p value], heterogeneity criteria for readmission reduced by 1.542 [1.284–1.851, < 0.001], I 2 = 60%, and 1.693 [1.645–1.744, < 0.001], I 2 = 60% for patients with a length of LTOT treatment under and above 8 months, respectively. A sensitivity analysis was conducted by systematically omitting each study, and it showed no influential studies. Egger’s test indicated no publication bias (p = 0.64). Conclusions Based on our results in this systematic review, long-tern oxygen therapy (LTOT) at home was associated with a significantly lower risk ratio of hospital readmission. However, the sample sizes in the studies necessitate larger RCTs to evaluate the effect of LTOT on readmission in COPD patients.https://doi.org/10.1007/s41030-023-00221-3COPDReadmissionLTOTHospitalization |
| spellingShingle | Ramin Sami Mahsa Akafzadeh Savari Marjan Mansourian Roghayeh Ghazavi Rokhsareh Meamar Effect of Long-Term Oxygen Therapy on Reducing Rehospitalization of Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis Pulmonary Therapy COPD Readmission LTOT Hospitalization |
| title | Effect of Long-Term Oxygen Therapy on Reducing Rehospitalization of Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis |
| title_full | Effect of Long-Term Oxygen Therapy on Reducing Rehospitalization of Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis |
| title_fullStr | Effect of Long-Term Oxygen Therapy on Reducing Rehospitalization of Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Effect of Long-Term Oxygen Therapy on Reducing Rehospitalization of Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis |
| title_short | Effect of Long-Term Oxygen Therapy on Reducing Rehospitalization of Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis |
| title_sort | effect of long term oxygen therapy on reducing rehospitalization of patients with chronic obstructive pulmonary disease a systematic review and meta analysis |
| topic | COPD Readmission LTOT Hospitalization |
| url | https://doi.org/10.1007/s41030-023-00221-3 |
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