Antioxidant Potential of Curcumin—A Meta-Analysis of Randomized Clinical Trials
Background: Antioxidant potential is defined as the ability to neutralize oxygen free radicals that are generated in excess due to environmental influences. The body’s defense mechanisms often require support in preventing the effects of oxidative stress. The literature data suggest that curcumin ha...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/11/1092 |
| _version_ | 1797548669353852928 |
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| author | Karolina Jakubczyk Aleksandra Drużga Janda Katarzyna Karolina Skonieczna-Żydecka |
| author_facet | Karolina Jakubczyk Aleksandra Drużga Janda Katarzyna Karolina Skonieczna-Żydecka |
| author_sort | Karolina Jakubczyk |
| collection | DOAJ |
| description | Background: Antioxidant potential is defined as the ability to neutralize oxygen free radicals that are generated in excess due to environmental influences. The body’s defense mechanisms often require support in preventing the effects of oxidative stress. The literature data suggest that curcumin has antioxidant activity that can significantly reduce oxidative stress levels. The aim was to assess the impact of curcumin on oxidative stress markers. Methods: PubMed and Embase were searched from database inception until 27 September 2019 for randomized clinical trials in >20 patients treated with curcumin supplements and randomized to placebo/no intervention/physical activity to verify the antioxidant potential of curcumin. Results: Four studies were included in the meta-analysis, three of which were double-blind and one single-blind. A total of 308 participants took part in the research. A total of 40% of the respondents were men. The average age of participants was 27.60 ± 3.79 years. The average supplementation time was 67 days and the average dose of curcumin administered was 645 mg/24 h. Curcumin significantly increased total antioxidant capacity (TAC) (SMD = 2.696, Z = 2.003, CI = 95%, <i>p</i> = 0.045) and had a tendency to decrease malondialdehyde (MDA) concentration (SMD = −1.579, Z = −1.714, CI = 95%, <i>p</i> = 0.086). Conclusions: Pure curcumin has the potential to reduce MDA concentration and increase total antioxidant capacity. |
| first_indexed | 2024-03-10T15:02:57Z |
| format | Article |
| id | doaj.art-4aab26e5f9ab40028ee284e0d94409cd |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T15:02:57Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-4aab26e5f9ab40028ee284e0d94409cd2023-11-20T20:00:02ZengMDPI AGAntioxidants2076-39212020-11-01911109210.3390/antiox9111092Antioxidant Potential of Curcumin—A Meta-Analysis of Randomized Clinical TrialsKarolina Jakubczyk0Aleksandra Drużga1Janda Katarzyna2Karolina Skonieczna-Żydecka3Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 24 Broniewskiego Street, 71-460 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 24 Broniewskiego Street, 71-460 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 24 Broniewskiego Street, 71-460 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 24 Broniewskiego Street, 71-460 Szczecin, PolandBackground: Antioxidant potential is defined as the ability to neutralize oxygen free radicals that are generated in excess due to environmental influences. The body’s defense mechanisms often require support in preventing the effects of oxidative stress. The literature data suggest that curcumin has antioxidant activity that can significantly reduce oxidative stress levels. The aim was to assess the impact of curcumin on oxidative stress markers. Methods: PubMed and Embase were searched from database inception until 27 September 2019 for randomized clinical trials in >20 patients treated with curcumin supplements and randomized to placebo/no intervention/physical activity to verify the antioxidant potential of curcumin. Results: Four studies were included in the meta-analysis, three of which were double-blind and one single-blind. A total of 308 participants took part in the research. A total of 40% of the respondents were men. The average age of participants was 27.60 ± 3.79 years. The average supplementation time was 67 days and the average dose of curcumin administered was 645 mg/24 h. Curcumin significantly increased total antioxidant capacity (TAC) (SMD = 2.696, Z = 2.003, CI = 95%, <i>p</i> = 0.045) and had a tendency to decrease malondialdehyde (MDA) concentration (SMD = −1.579, Z = −1.714, CI = 95%, <i>p</i> = 0.086). Conclusions: Pure curcumin has the potential to reduce MDA concentration and increase total antioxidant capacity.https://www.mdpi.com/2076-3921/9/11/1092curcuminpolyphenolantioxidantoxidative stressturmericIndian saffron |
| spellingShingle | Karolina Jakubczyk Aleksandra Drużga Janda Katarzyna Karolina Skonieczna-Żydecka Antioxidant Potential of Curcumin—A Meta-Analysis of Randomized Clinical Trials Antioxidants curcumin polyphenol antioxidant oxidative stress turmeric Indian saffron |
| title | Antioxidant Potential of Curcumin—A Meta-Analysis of Randomized Clinical Trials |
| title_full | Antioxidant Potential of Curcumin—A Meta-Analysis of Randomized Clinical Trials |
| title_fullStr | Antioxidant Potential of Curcumin—A Meta-Analysis of Randomized Clinical Trials |
| title_full_unstemmed | Antioxidant Potential of Curcumin—A Meta-Analysis of Randomized Clinical Trials |
| title_short | Antioxidant Potential of Curcumin—A Meta-Analysis of Randomized Clinical Trials |
| title_sort | antioxidant potential of curcumin a meta analysis of randomized clinical trials |
| topic | curcumin polyphenol antioxidant oxidative stress turmeric Indian saffron |
| url | https://www.mdpi.com/2076-3921/9/11/1092 |
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