A Review of the Biological Activity of Amidrazone Derivatives
Amidrazones are widely used in chemical synthesis, industry and agriculture. We compiled some of the most important findings on the biological activities of amidrazones described in the years 2010–2022. The data were obtained using the ScienceDirect, Reaxys and Google Scholar search engines with key...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/10/1219 |
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| author | Renata Paprocka Małgorzata Wiese-Szadkowska Tomasz Kosmalski Daria Frisch Magdalena Ratajczak Bożena Modzelewska-Banachiewicz Renata Studzińska |
| author_facet | Renata Paprocka Małgorzata Wiese-Szadkowska Tomasz Kosmalski Daria Frisch Magdalena Ratajczak Bożena Modzelewska-Banachiewicz Renata Studzińska |
| author_sort | Renata Paprocka |
| collection | DOAJ |
| description | Amidrazones are widely used in chemical synthesis, industry and agriculture. We compiled some of the most important findings on the biological activities of amidrazones described in the years 2010–2022. The data were obtained using the ScienceDirect, Reaxys and Google Scholar search engines with keywords (amidrazone, carbohydrazonamide, carboximidohydrazide, aminoguanidine) and structure strategies. Compounds with significant biological activities were included in the review. The described structures derived from amidrazones include: amidrazone derivatives; aminoguanidine derivatives; complexes obtained using amidrazones as ligands; and some cyclic compounds obtained from amidrazones and/or containing an amidrazone moiety in their structures. This review includes chapters based on compound activities, including: tuberculostatic, antibacterial, antifungal, antiparasitic, antiviral, anti-inflammatory, cytoprotective, and antitumor compounds, as well as furin and acetylocholinesterase inhibitors. Detailed information on the compounds tested in vivo, along the mechanisms of action and toxicity of the selected amidrazone derivatives, are described. We describe examples of compounds that have a chance of becoming drugs due to promising preclinical or clinical research, as well as old drugs with new therapeutic targets (repositioning) which have the potential to be used in the treatment of other diseases. The described examples prove that amidrazone derivatives are a potential source of new therapeutic substances and deserve further research. |
| first_indexed | 2024-03-09T19:36:29Z |
| format | Article |
| id | doaj.art-4aab98097ad74724b3f6ec031156a1bd |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T19:36:29Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-4aab98097ad74724b3f6ec031156a1bd2023-11-24T01:51:17ZengMDPI AGPharmaceuticals1424-82472022-09-011510121910.3390/ph15101219A Review of the Biological Activity of Amidrazone DerivativesRenata Paprocka0Małgorzata Wiese-Szadkowska1Tomasz Kosmalski2Daria Frisch3Magdalena Ratajczak4Bożena Modzelewska-Banachiewicz5Renata Studzińska6Department of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Jurasza Str. 2, 85-089 Bydgoszcz, PolandDepartment of Immunology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, M. Curie-Skłodowska Str. 9, 85-094 Bydgoszcz, PolandDepartment of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Jurasza Str. 2, 85-089 Bydgoszcz, PolandDepartment of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Jurasza Str. 2, 85-089 Bydgoszcz, PolandDepartment of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Jurasza Str. 2, 85-089 Bydgoszcz, PolandDepartment of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Jurasza Str. 2, 85-089 Bydgoszcz, PolandDepartment of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Jurasza Str. 2, 85-089 Bydgoszcz, PolandAmidrazones are widely used in chemical synthesis, industry and agriculture. We compiled some of the most important findings on the biological activities of amidrazones described in the years 2010–2022. The data were obtained using the ScienceDirect, Reaxys and Google Scholar search engines with keywords (amidrazone, carbohydrazonamide, carboximidohydrazide, aminoguanidine) and structure strategies. Compounds with significant biological activities were included in the review. The described structures derived from amidrazones include: amidrazone derivatives; aminoguanidine derivatives; complexes obtained using amidrazones as ligands; and some cyclic compounds obtained from amidrazones and/or containing an amidrazone moiety in their structures. This review includes chapters based on compound activities, including: tuberculostatic, antibacterial, antifungal, antiparasitic, antiviral, anti-inflammatory, cytoprotective, and antitumor compounds, as well as furin and acetylocholinesterase inhibitors. Detailed information on the compounds tested in vivo, along the mechanisms of action and toxicity of the selected amidrazone derivatives, are described. We describe examples of compounds that have a chance of becoming drugs due to promising preclinical or clinical research, as well as old drugs with new therapeutic targets (repositioning) which have the potential to be used in the treatment of other diseases. The described examples prove that amidrazone derivatives are a potential source of new therapeutic substances and deserve further research.https://www.mdpi.com/1424-8247/15/10/1219amidrazoneaminoguanidineantibacterialantifungalantiparasiticantitumor |
| spellingShingle | Renata Paprocka Małgorzata Wiese-Szadkowska Tomasz Kosmalski Daria Frisch Magdalena Ratajczak Bożena Modzelewska-Banachiewicz Renata Studzińska A Review of the Biological Activity of Amidrazone Derivatives Pharmaceuticals amidrazone aminoguanidine antibacterial antifungal antiparasitic antitumor |
| title | A Review of the Biological Activity of Amidrazone Derivatives |
| title_full | A Review of the Biological Activity of Amidrazone Derivatives |
| title_fullStr | A Review of the Biological Activity of Amidrazone Derivatives |
| title_full_unstemmed | A Review of the Biological Activity of Amidrazone Derivatives |
| title_short | A Review of the Biological Activity of Amidrazone Derivatives |
| title_sort | review of the biological activity of amidrazone derivatives |
| topic | amidrazone aminoguanidine antibacterial antifungal antiparasitic antitumor |
| url | https://www.mdpi.com/1424-8247/15/10/1219 |
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