Microglia activation in central nervous system disorders: A review of recent mechanistic investigations and development efforts
Microglia are the principal resident immune cells in the central nervous system (CNS) and play important roles in the development of CNS disorders. In recent years, there have been significant developments in our understanding of microglia, and we now have greater insight into the temporal and spati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1103416/full |
| _version_ | 1811158965134819328 |
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| author | Jun Qin Zhihui Ma Xiaoli Chen Shiyu Shu |
| author_facet | Jun Qin Zhihui Ma Xiaoli Chen Shiyu Shu |
| author_sort | Jun Qin |
| collection | DOAJ |
| description | Microglia are the principal resident immune cells in the central nervous system (CNS) and play important roles in the development of CNS disorders. In recent years, there have been significant developments in our understanding of microglia, and we now have greater insight into the temporal and spatial patterns of microglia activation in a variety of CNS disorders, as well as the interactions between microglia and neurons. A variety of signaling pathways have been implicated. However, to date, all published clinical trials have failed to demonstrate efficacy over placebo. This review summarizes the results of recent important studies and attempts to provide a mechanistic view of microglia activation, inflammation, tissue repair, and CNS disorders. |
| first_indexed | 2024-04-10T05:33:16Z |
| format | Article |
| id | doaj.art-4aac7828fc51478da919bbd935ffd254 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T05:33:16Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-4aac7828fc51478da919bbd935ffd2542023-03-07T05:09:43ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-03-011410.3389/fneur.2023.11034161103416Microglia activation in central nervous system disorders: A review of recent mechanistic investigations and development effortsJun QinZhihui MaXiaoli ChenShiyu ShuMicroglia are the principal resident immune cells in the central nervous system (CNS) and play important roles in the development of CNS disorders. In recent years, there have been significant developments in our understanding of microglia, and we now have greater insight into the temporal and spatial patterns of microglia activation in a variety of CNS disorders, as well as the interactions between microglia and neurons. A variety of signaling pathways have been implicated. However, to date, all published clinical trials have failed to demonstrate efficacy over placebo. This review summarizes the results of recent important studies and attempts to provide a mechanistic view of microglia activation, inflammation, tissue repair, and CNS disorders.https://www.frontiersin.org/articles/10.3389/fneur.2023.1103416/fullmicrogliaactivationmembrane receptorsignaling pathwayinflammatory response |
| spellingShingle | Jun Qin Zhihui Ma Xiaoli Chen Shiyu Shu Microglia activation in central nervous system disorders: A review of recent mechanistic investigations and development efforts Frontiers in Neurology microglia activation membrane receptor signaling pathway inflammatory response |
| title | Microglia activation in central nervous system disorders: A review of recent mechanistic investigations and development efforts |
| title_full | Microglia activation in central nervous system disorders: A review of recent mechanistic investigations and development efforts |
| title_fullStr | Microglia activation in central nervous system disorders: A review of recent mechanistic investigations and development efforts |
| title_full_unstemmed | Microglia activation in central nervous system disorders: A review of recent mechanistic investigations and development efforts |
| title_short | Microglia activation in central nervous system disorders: A review of recent mechanistic investigations and development efforts |
| title_sort | microglia activation in central nervous system disorders a review of recent mechanistic investigations and development efforts |
| topic | microglia activation membrane receptor signaling pathway inflammatory response |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1103416/full |
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