Severity Biomarkers in Puumala Hantavirus Infection
Annually, over 10,000 cases of hemorrhagic fever with renal syndrome (HFRS) are diagnosed in Europe. Puumala hantavirus (PUUV) causes most of the European HFRS cases. PUUV causes usually a relatively mild disease, which is rarely fatal. However, the severity of the infection varies greatly, and fact...
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MDPI AG
2021-12-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/1/45 |
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| author | Tuula K. Outinen Satu Mäkelä Ilkka Pörsti Antti Vaheri Jukka Mustonen |
| author_facet | Tuula K. Outinen Satu Mäkelä Ilkka Pörsti Antti Vaheri Jukka Mustonen |
| author_sort | Tuula K. Outinen |
| collection | DOAJ |
| description | Annually, over 10,000 cases of hemorrhagic fever with renal syndrome (HFRS) are diagnosed in Europe. Puumala hantavirus (PUUV) causes most of the European HFRS cases. PUUV causes usually a relatively mild disease, which is rarely fatal. However, the severity of the infection varies greatly, and factors affecting the severity are mostly unrevealed. Host genes are known to have an effect. The typical clinical features in PUUV infection include acute kidney injury, thrombocytopenia, and increased vascular permeability. The primary target of hantavirus is the endothelium of the vessels of different organs. Although PUUV does not cause direct cytopathology of the endothelial cells, remarkable changes in both the barrier function of the endothelium and the function of the infected endothelial cells occur. Host immune or inflammatory mechanisms are probably important in the development of the capillary leakage. Several immunoinflammatory biomarkers have been studied in the context of assessing the severity of HFRS caused by PUUV. Most of them are not used in clinical practice, but the increasing knowledge about the biomarkers has elucidated the pathogenesis of PUUV infection. |
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| format | Article |
| id | doaj.art-4aadd0ed94754cedab2080fb255932ab |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T00:21:43Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-4aadd0ed94754cedab2080fb255932ab2023-11-23T15:41:16ZengMDPI AGViruses1999-49152021-12-011414510.3390/v14010045Severity Biomarkers in Puumala Hantavirus InfectionTuula K. Outinen0Satu Mäkelä1Ilkka Pörsti2Antti Vaheri3Jukka Mustonen4Department of Internal Medicine, Tampere University Hospital, Elämänaukio 2, 33520 Tampere, FinlandDepartment of Internal Medicine, Tampere University Hospital, Elämänaukio 2, 33520 Tampere, FinlandDepartment of Internal Medicine, Tampere University Hospital, Elämänaukio 2, 33520 Tampere, FinlandDepartment of Virology, Medicum, University of Helsinki, 00290 Helsinki, FinlandDepartment of Internal Medicine, Tampere University Hospital, Elämänaukio 2, 33520 Tampere, FinlandAnnually, over 10,000 cases of hemorrhagic fever with renal syndrome (HFRS) are diagnosed in Europe. Puumala hantavirus (PUUV) causes most of the European HFRS cases. PUUV causes usually a relatively mild disease, which is rarely fatal. However, the severity of the infection varies greatly, and factors affecting the severity are mostly unrevealed. Host genes are known to have an effect. The typical clinical features in PUUV infection include acute kidney injury, thrombocytopenia, and increased vascular permeability. The primary target of hantavirus is the endothelium of the vessels of different organs. Although PUUV does not cause direct cytopathology of the endothelial cells, remarkable changes in both the barrier function of the endothelium and the function of the infected endothelial cells occur. Host immune or inflammatory mechanisms are probably important in the development of the capillary leakage. Several immunoinflammatory biomarkers have been studied in the context of assessing the severity of HFRS caused by PUUV. Most of them are not used in clinical practice, but the increasing knowledge about the biomarkers has elucidated the pathogenesis of PUUV infection.https://www.mdpi.com/1999-4915/14/1/45hantavirushemorrhagic fever with renal syndromePuumala virusbiomarker |
| spellingShingle | Tuula K. Outinen Satu Mäkelä Ilkka Pörsti Antti Vaheri Jukka Mustonen Severity Biomarkers in Puumala Hantavirus Infection Viruses hantavirus hemorrhagic fever with renal syndrome Puumala virus biomarker |
| title | Severity Biomarkers in Puumala Hantavirus Infection |
| title_full | Severity Biomarkers in Puumala Hantavirus Infection |
| title_fullStr | Severity Biomarkers in Puumala Hantavirus Infection |
| title_full_unstemmed | Severity Biomarkers in Puumala Hantavirus Infection |
| title_short | Severity Biomarkers in Puumala Hantavirus Infection |
| title_sort | severity biomarkers in puumala hantavirus infection |
| topic | hantavirus hemorrhagic fever with renal syndrome Puumala virus biomarker |
| url | https://www.mdpi.com/1999-4915/14/1/45 |
| work_keys_str_mv | AT tuulakoutinen severitybiomarkersinpuumalahantavirusinfection AT satumakela severitybiomarkersinpuumalahantavirusinfection AT ilkkaporsti severitybiomarkersinpuumalahantavirusinfection AT anttivaheri severitybiomarkersinpuumalahantavirusinfection AT jukkamustonen severitybiomarkersinpuumalahantavirusinfection |