Hypertension and Life-Threatening Bleeding in Children with Relapsed Acute Myeloblastic Leukemia Treated with FLT3 Inhibitors
Experiences with new multikinase inhibitors are limited, especially in children. In this report we summarize our experience with 2 patients with relapsed acute myeloblastic leukemia (AML), one with FMS-like tyrosine kinase- 3-internal tandem duplication mutation and the other with a single base muta...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2015-07-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-57984 |
| _version_ | 1797912501042544640 |
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| author | Deniz Yılmaz Karapınar Nihal Karadaş Zühal Önder Siviş Can Balkan Kaan Kavaklı Yeşim Aydınok |
| author_facet | Deniz Yılmaz Karapınar Nihal Karadaş Zühal Önder Siviş Can Balkan Kaan Kavaklı Yeşim Aydınok |
| author_sort | Deniz Yılmaz Karapınar |
| collection | DOAJ |
| description | Experiences with new multikinase inhibitors are limited, especially in children. In this report we summarize our experience with 2 patients with relapsed acute myeloblastic leukemia (AML), one with FMS-like tyrosine kinase- 3-internal tandem duplication mutation and the other with a single base mutation (D835Y). Both patients received sorafenib, one for 19 days and the other for 42 days, with clofarabine-including chemotherapy. One additionally received sunitinib for a total of 20 days. Both patients developed severe pancytopenia, hypertension, life-threatening bleedings from the gastrointestinal system, and, finally, intrapulmonary hemorrhage. Although both reached severe aplasia of the bone marrow without blastic infiltration, death occurred with neutropenic sepsis. |
| first_indexed | 2024-04-10T11:56:52Z |
| format | Article |
| id | doaj.art-4aaee46483bc4db2ad6ee144b0356c68 |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T11:56:52Z |
| publishDate | 2015-07-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-4aaee46483bc4db2ad6ee144b0356c682023-02-15T16:16:47ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632015-07-0132326326610.4274/tjh.2014.0250TJH-57984Hypertension and Life-Threatening Bleeding in Children with Relapsed Acute Myeloblastic Leukemia Treated with FLT3 InhibitorsDeniz Yılmaz Karapınar0Nihal Karadaş1Zühal Önder Siviş2Can Balkan3Kaan Kavaklı4Yeşim Aydınok5Ege University Faculty of Medicine, Department of Pediatric Hematology, İzmir, TurkeyEge University Faculty of Medicine, Department of Pediatric Hematology, İzmir, TurkeyEge University Faculty of Medicine, Department of Pediatric Hematology, İzmir, TurkeyEge University Faculty of Medicine, Department of Pediatric Hematology, İzmir, TurkeyEge University Faculty of Medicine, Department of Pediatric Hematology, İzmir, TurkeyEge University Faculty of Medicine, Department of Pediatric Hematology, İzmir, TurkeyExperiences with new multikinase inhibitors are limited, especially in children. In this report we summarize our experience with 2 patients with relapsed acute myeloblastic leukemia (AML), one with FMS-like tyrosine kinase- 3-internal tandem duplication mutation and the other with a single base mutation (D835Y). Both patients received sorafenib, one for 19 days and the other for 42 days, with clofarabine-including chemotherapy. One additionally received sunitinib for a total of 20 days. Both patients developed severe pancytopenia, hypertension, life-threatening bleedings from the gastrointestinal system, and, finally, intrapulmonary hemorrhage. Although both reached severe aplasia of the bone marrow without blastic infiltration, death occurred with neutropenic sepsis.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-57984acute myeloblastic leukemiaflt3sorafenibsunitinibchildrend835y mutation |
| spellingShingle | Deniz Yılmaz Karapınar Nihal Karadaş Zühal Önder Siviş Can Balkan Kaan Kavaklı Yeşim Aydınok Hypertension and Life-Threatening Bleeding in Children with Relapsed Acute Myeloblastic Leukemia Treated with FLT3 Inhibitors Turkish Journal of Hematology acute myeloblastic leukemia flt3 sorafenib sunitinib children d835y mutation |
| title | Hypertension and Life-Threatening Bleeding in Children with Relapsed Acute Myeloblastic Leukemia Treated with FLT3 Inhibitors |
| title_full | Hypertension and Life-Threatening Bleeding in Children with Relapsed Acute Myeloblastic Leukemia Treated with FLT3 Inhibitors |
| title_fullStr | Hypertension and Life-Threatening Bleeding in Children with Relapsed Acute Myeloblastic Leukemia Treated with FLT3 Inhibitors |
| title_full_unstemmed | Hypertension and Life-Threatening Bleeding in Children with Relapsed Acute Myeloblastic Leukemia Treated with FLT3 Inhibitors |
| title_short | Hypertension and Life-Threatening Bleeding in Children with Relapsed Acute Myeloblastic Leukemia Treated with FLT3 Inhibitors |
| title_sort | hypertension and life threatening bleeding in children with relapsed acute myeloblastic leukemia treated with flt3 inhibitors |
| topic | acute myeloblastic leukemia flt3 sorafenib sunitinib children d835y mutation |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-57984 |
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