Expression of BAG1 is associated with prognosis in kidney renal clear cell carcinoma based on bioinformatics
Abstract Background BCL2 associated Athano-Gene 1 (BAG1) has been described to be involved in the development and progression of cancer. But the role of BAG1 in kidney renal clear cell carcinoma (KIRC) has remained largely unknown. Methods We performed bioinformatic analysis of data from TCGA and GE...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-021-07874-w |
| _version_ | 1818946109151641600 |
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| author | Hongrong Wu Minjing Liu Yuejun He Guozhao Meng Wanbei Guo Qiong Guo |
| author_facet | Hongrong Wu Minjing Liu Yuejun He Guozhao Meng Wanbei Guo Qiong Guo |
| author_sort | Hongrong Wu |
| collection | DOAJ |
| description | Abstract Background BCL2 associated Athano-Gene 1 (BAG1) has been described to be involved in the development and progression of cancer. But the role of BAG1 in kidney renal clear cell carcinoma (KIRC) has remained largely unknown. Methods We performed bioinformatic analysis of data from TCGA and GEO dataset. The role of BAG1 in KIRC was explored by Logistic and Cox regression model. The molecular mechanisms of BAG1 was revealed by GSEA. Results The current study found that the KIRC tumor samples have a low level of BAG1 mRNA expression compared to the matched normal tissues based on TCGA data and GEO databases. Low expression of BAG1 in KIRC was significantly associated with Sex, clinical pathological stage, tumor-node-metastasis (TNM) stage, hemoglobin levels, cancer status and history of neoadjuvant treatment. Kaplan-Meier survival analysis indicated that KIRC patients with BAG1 high expression have a longer survival time than those with BAG1 low expression (p < 0.000). Cox regression analysis showed that BAG1 remained independently associated with overall survival, with a hazard ratio (HR) of 1.75(CI:1.05–2.90; p = 0.029). GSEA indicated that the signaling pathways including fatty acid metabolism and oxidative phosphorylation were differentially enriched in high BAG1 expression phenotype. Conclusions These findings suggested that BAG1 expression may act as a potential favorable prognostic marker and challenging therapeutic target. |
| first_indexed | 2024-12-20T08:09:47Z |
| format | Article |
| id | doaj.art-4aaf274f8c374d549d29f958ff4ad588 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-20T08:09:47Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-4aaf274f8c374d549d29f958ff4ad5882022-12-21T19:47:18ZengBMCBMC Cancer1471-24072021-02-012111810.1186/s12885-021-07874-wExpression of BAG1 is associated with prognosis in kidney renal clear cell carcinoma based on bioinformaticsHongrong Wu0Minjing Liu1Yuejun He2Guozhao Meng3Wanbei Guo4Qiong Guo5Department of Pathology, the Affiliated Hospital of Guangdong Medical UniversityInstitute of Basic Disease Sciences, XiangNan UniversityDepartment of Supervision, Baiyun International Airport Customs’ InspectionInstitute of Basic Disease Sciences, XiangNan UniversityInstitute of Basic Disease Sciences, XiangNan UniversityDepartment of Urology, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal UniversityAbstract Background BCL2 associated Athano-Gene 1 (BAG1) has been described to be involved in the development and progression of cancer. But the role of BAG1 in kidney renal clear cell carcinoma (KIRC) has remained largely unknown. Methods We performed bioinformatic analysis of data from TCGA and GEO dataset. The role of BAG1 in KIRC was explored by Logistic and Cox regression model. The molecular mechanisms of BAG1 was revealed by GSEA. Results The current study found that the KIRC tumor samples have a low level of BAG1 mRNA expression compared to the matched normal tissues based on TCGA data and GEO databases. Low expression of BAG1 in KIRC was significantly associated with Sex, clinical pathological stage, tumor-node-metastasis (TNM) stage, hemoglobin levels, cancer status and history of neoadjuvant treatment. Kaplan-Meier survival analysis indicated that KIRC patients with BAG1 high expression have a longer survival time than those with BAG1 low expression (p < 0.000). Cox regression analysis showed that BAG1 remained independently associated with overall survival, with a hazard ratio (HR) of 1.75(CI:1.05–2.90; p = 0.029). GSEA indicated that the signaling pathways including fatty acid metabolism and oxidative phosphorylation were differentially enriched in high BAG1 expression phenotype. Conclusions These findings suggested that BAG1 expression may act as a potential favorable prognostic marker and challenging therapeutic target.https://doi.org/10.1186/s12885-021-07874-wBAG1PrognosisKIRCFatty acid metabolismOxidative phosphorylation |
| spellingShingle | Hongrong Wu Minjing Liu Yuejun He Guozhao Meng Wanbei Guo Qiong Guo Expression of BAG1 is associated with prognosis in kidney renal clear cell carcinoma based on bioinformatics BMC Cancer BAG1 Prognosis KIRC Fatty acid metabolism Oxidative phosphorylation |
| title | Expression of BAG1 is associated with prognosis in kidney renal clear cell carcinoma based on bioinformatics |
| title_full | Expression of BAG1 is associated with prognosis in kidney renal clear cell carcinoma based on bioinformatics |
| title_fullStr | Expression of BAG1 is associated with prognosis in kidney renal clear cell carcinoma based on bioinformatics |
| title_full_unstemmed | Expression of BAG1 is associated with prognosis in kidney renal clear cell carcinoma based on bioinformatics |
| title_short | Expression of BAG1 is associated with prognosis in kidney renal clear cell carcinoma based on bioinformatics |
| title_sort | expression of bag1 is associated with prognosis in kidney renal clear cell carcinoma based on bioinformatics |
| topic | BAG1 Prognosis KIRC Fatty acid metabolism Oxidative phosphorylation |
| url | https://doi.org/10.1186/s12885-021-07874-w |
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