4-Fluoro-N’-(2-hydroxy-3-methoxybenzylidene)benzohydrazide and its oxidovanadium(V) complex: Syntheses, crystal structures and insulin-enhancing activity
A hydrated hydrazone compound, 4-fluoro-N'-(2-hydroxy-3-methoxybenzylidene)benzohydrazide monohydrate (H2L·H2O), was prepared and characterized by elemental analysis, HRMS, IR, UV-Vis and 1H NMR spectroscopy. Reaction of H2L, kojic acid (5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one; Hka) and VO(a...
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| Format: | Article |
| Language: | English |
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Slovenian Chemical Society
2016-07-01
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| Series: | Acta Chimica Slovenica |
| Subjects: | |
| Online Access: | https://journals.matheo.si/index.php/ACSi/article/view/2589 |
| _version_ | 1819265566880301056 |
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| author | Jin-Xian Lei Jing Wang Yang Huo Zhonglu You |
| author_facet | Jin-Xian Lei Jing Wang Yang Huo Zhonglu You |
| author_sort | Jin-Xian Lei |
| collection | DOAJ |
| description | A hydrated hydrazone compound, 4-fluoro-N'-(2-hydroxy-3-methoxybenzylidene)benzohydrazide monohydrate (H2L·H2O), was prepared and characterized by elemental analysis, HRMS, IR, UV-Vis and 1H NMR spectroscopy. Reaction of H2L, kojic acid (5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one; Hka) and VO(acac)2 in methanol afforded a novel oxidovanadium(V) complex, [VO(ka)L]. The complex was characterized by elemental analysis, IR, UV-Vis and 1H NMR spectroscopy. Thermal analysis was also performed. Structures of H2L and the complex were further confirmed by single crystal structural X-ray diffraction. The vanadium complex is the first structurally characterized vanadium complex of kojic acid. Insulin-mimetic tests on C2C12 muscle cells indicate that the complex significantly stimulated cell glucose utilization with cytotoxicity at 0.11 g L–1. |
| first_indexed | 2024-12-23T20:47:25Z |
| format | Article |
| id | doaj.art-4ab153257dfe4aafb9493c96c4910213 |
| institution | Directory Open Access Journal |
| issn | 1318-0207 1580-3155 |
| language | English |
| last_indexed | 2024-12-23T20:47:25Z |
| publishDate | 2016-07-01 |
| publisher | Slovenian Chemical Society |
| record_format | Article |
| series | Acta Chimica Slovenica |
| spelling | doaj.art-4ab153257dfe4aafb9493c96c49102132022-12-21T17:31:44ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552016-07-0163367067710.17344/acsi.2016.25893804-Fluoro-N’-(2-hydroxy-3-methoxybenzylidene)benzohydrazide and its oxidovanadium(V) complex: Syntheses, crystal structures and insulin-enhancing activityJin-Xian Lei0Jing WangYang HuoZhonglu YouJinzhong UniversityA hydrated hydrazone compound, 4-fluoro-N'-(2-hydroxy-3-methoxybenzylidene)benzohydrazide monohydrate (H2L·H2O), was prepared and characterized by elemental analysis, HRMS, IR, UV-Vis and 1H NMR spectroscopy. Reaction of H2L, kojic acid (5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one; Hka) and VO(acac)2 in methanol afforded a novel oxidovanadium(V) complex, [VO(ka)L]. The complex was characterized by elemental analysis, IR, UV-Vis and 1H NMR spectroscopy. Thermal analysis was also performed. Structures of H2L and the complex were further confirmed by single crystal structural X-ray diffraction. The vanadium complex is the first structurally characterized vanadium complex of kojic acid. Insulin-mimetic tests on C2C12 muscle cells indicate that the complex significantly stimulated cell glucose utilization with cytotoxicity at 0.11 g L–1.https://journals.matheo.si/index.php/ACSi/article/view/2589Oxovanadium complexKojic acidaroylhydrazonecrystal structureinsulin-enhancing activity |
| spellingShingle | Jin-Xian Lei Jing Wang Yang Huo Zhonglu You 4-Fluoro-N’-(2-hydroxy-3-methoxybenzylidene)benzohydrazide and its oxidovanadium(V) complex: Syntheses, crystal structures and insulin-enhancing activity Acta Chimica Slovenica Oxovanadium complex Kojic acid aroylhydrazone crystal structure insulin-enhancing activity |
| title | 4-Fluoro-N’-(2-hydroxy-3-methoxybenzylidene)benzohydrazide and its oxidovanadium(V) complex: Syntheses, crystal structures and insulin-enhancing activity |
| title_full | 4-Fluoro-N’-(2-hydroxy-3-methoxybenzylidene)benzohydrazide and its oxidovanadium(V) complex: Syntheses, crystal structures and insulin-enhancing activity |
| title_fullStr | 4-Fluoro-N’-(2-hydroxy-3-methoxybenzylidene)benzohydrazide and its oxidovanadium(V) complex: Syntheses, crystal structures and insulin-enhancing activity |
| title_full_unstemmed | 4-Fluoro-N’-(2-hydroxy-3-methoxybenzylidene)benzohydrazide and its oxidovanadium(V) complex: Syntheses, crystal structures and insulin-enhancing activity |
| title_short | 4-Fluoro-N’-(2-hydroxy-3-methoxybenzylidene)benzohydrazide and its oxidovanadium(V) complex: Syntheses, crystal structures and insulin-enhancing activity |
| title_sort | 4 fluoro n 2 hydroxy 3 methoxybenzylidene benzohydrazide and its oxidovanadium v complex syntheses crystal structures and insulin enhancing activity |
| topic | Oxovanadium complex Kojic acid aroylhydrazone crystal structure insulin-enhancing activity |
| url | https://journals.matheo.si/index.php/ACSi/article/view/2589 |
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