Application of Metabolomics in Obesity-Related Childhood Asthma Subtyping: A Narrative Scoping Review
Obesity-related asthma is a heterogeneous childhood asthma phenotype with rising prevalence. Observational studies identify early-life obesity or weight gain as risk factors for childhood asthma development. The reverse association is also described, children with asthma have a higher risk of being...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/3/328 |
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| author | Heidi Makrinioti Zhaozhong Zhu Carlos A. Camargo Valentina Fainardi Kohei Hasegawa Andrew Bush Sejal Saglani |
| author_facet | Heidi Makrinioti Zhaozhong Zhu Carlos A. Camargo Valentina Fainardi Kohei Hasegawa Andrew Bush Sejal Saglani |
| author_sort | Heidi Makrinioti |
| collection | DOAJ |
| description | Obesity-related asthma is a heterogeneous childhood asthma phenotype with rising prevalence. Observational studies identify early-life obesity or weight gain as risk factors for childhood asthma development. The reverse association is also described, children with asthma have a higher risk of being obese. Obese children with asthma have poor symptom control and an increased number of asthma attacks compared to non-obese children with asthma. Clinical trials have also identified that a proportion of obese children with asthma do not respond as well to usual treatment (e.g., inhaled corticosteroids). The heterogeneity of obesity-related asthma phenotypes may be attributable to different underlying pathogenetic mechanisms. Although few childhood obesity-related asthma endotypes have been described, our knowledge in this field is incomplete. An evolving analytical profiling technique, metabolomics, has the potential to link individuals’ genetic backgrounds and environmental exposures (e.g., diet) to disease endotypes. This will ultimately help define clinically relevant obesity-related childhood asthma subtypes that respond better to targeted treatment. However, there are challenges related to this approach. The current narrative scoping review summarizes the evidence for metabolomics contributing to asthma subtyping in obese children, highlights the challenges associated with the implementation of this approach, and identifies gaps in research. |
| first_indexed | 2024-03-11T06:11:14Z |
| format | Article |
| id | doaj.art-4ab166ff68044d01b9bca063c8345e61 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T06:11:14Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-4ab166ff68044d01b9bca063c8345e612023-11-17T12:35:57ZengMDPI AGMetabolites2218-19892023-02-0113332810.3390/metabo13030328Application of Metabolomics in Obesity-Related Childhood Asthma Subtyping: A Narrative Scoping ReviewHeidi Makrinioti0Zhaozhong Zhu1Carlos A. Camargo2Valentina Fainardi3Kohei Hasegawa4Andrew Bush5Sejal Saglani6Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USADepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USADepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USAClinica Pediatrica, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USANational Heart and Lung Institute, Imperial College, London SW7 2AZ, UKNational Heart and Lung Institute, Imperial College, London SW7 2AZ, UKObesity-related asthma is a heterogeneous childhood asthma phenotype with rising prevalence. Observational studies identify early-life obesity or weight gain as risk factors for childhood asthma development. The reverse association is also described, children with asthma have a higher risk of being obese. Obese children with asthma have poor symptom control and an increased number of asthma attacks compared to non-obese children with asthma. Clinical trials have also identified that a proportion of obese children with asthma do not respond as well to usual treatment (e.g., inhaled corticosteroids). The heterogeneity of obesity-related asthma phenotypes may be attributable to different underlying pathogenetic mechanisms. Although few childhood obesity-related asthma endotypes have been described, our knowledge in this field is incomplete. An evolving analytical profiling technique, metabolomics, has the potential to link individuals’ genetic backgrounds and environmental exposures (e.g., diet) to disease endotypes. This will ultimately help define clinically relevant obesity-related childhood asthma subtypes that respond better to targeted treatment. However, there are challenges related to this approach. The current narrative scoping review summarizes the evidence for metabolomics contributing to asthma subtyping in obese children, highlights the challenges associated with the implementation of this approach, and identifies gaps in research.https://www.mdpi.com/2218-1989/13/3/328obesityasthmasubtypingmetabolomicsendotypes |
| spellingShingle | Heidi Makrinioti Zhaozhong Zhu Carlos A. Camargo Valentina Fainardi Kohei Hasegawa Andrew Bush Sejal Saglani Application of Metabolomics in Obesity-Related Childhood Asthma Subtyping: A Narrative Scoping Review Metabolites obesity asthma subtyping metabolomics endotypes |
| title | Application of Metabolomics in Obesity-Related Childhood Asthma Subtyping: A Narrative Scoping Review |
| title_full | Application of Metabolomics in Obesity-Related Childhood Asthma Subtyping: A Narrative Scoping Review |
| title_fullStr | Application of Metabolomics in Obesity-Related Childhood Asthma Subtyping: A Narrative Scoping Review |
| title_full_unstemmed | Application of Metabolomics in Obesity-Related Childhood Asthma Subtyping: A Narrative Scoping Review |
| title_short | Application of Metabolomics in Obesity-Related Childhood Asthma Subtyping: A Narrative Scoping Review |
| title_sort | application of metabolomics in obesity related childhood asthma subtyping a narrative scoping review |
| topic | obesity asthma subtyping metabolomics endotypes |
| url | https://www.mdpi.com/2218-1989/13/3/328 |
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