High Intensity Violet Light (405 nm) Inactivates Coronaviruses in Phosphate Buffered Saline (PBS) and on Surfaces
It has been proven that visible light with a wavelength of about 405 nm exhibits an antimicrobial effect on bacteria and fungi if the irradiation doses are high enough. Hence, the question arises as to whether this violet light would also be suitable to inactivate SARS-CoV-2 coronaviruses. Therefore...
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MDPI AG
2021-09-01
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| Series: | Photonics |
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| Online Access: | https://www.mdpi.com/2304-6732/8/10/414 |
| _version_ | 1827678736694116352 |
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| author | Bernhard Lau Dietmar Becher Martin Hessling |
| author_facet | Bernhard Lau Dietmar Becher Martin Hessling |
| author_sort | Bernhard Lau |
| collection | DOAJ |
| description | It has been proven that visible light with a wavelength of about 405 nm exhibits an antimicrobial effect on bacteria and fungi if the irradiation doses are high enough. Hence, the question arises as to whether this violet light would also be suitable to inactivate SARS-CoV-2 coronaviruses. Therefore, a high-intensity light source was developed and applied to irradiate bovine coronaviruses (BCoV), which are employed as SARS-CoV-2 surrogates for safety reasons. Irradiation is performed in virus solutions diluted with phosphate buffered saline and on steel surfaces. Significant virus reduction by several log levels was observed both in the liquid and on the surface within half an hour with average log reduction doses of 57.5 and 96 J/cm<sup>2</sup>, respectively. Therefore, it can be concluded that 405 nm irradiation has an antiviral effect on coronaviruses, but special attention should be paid to the presence of photosensitizers in the virus environment in future experiments. Technically, visible violet radiation is therefore suitable for coronavirus reduction, but the required radiation doses are difficult to achieve rapidly. |
| first_indexed | 2024-03-10T06:16:09Z |
| format | Article |
| id | doaj.art-4ab16b09ba6449279f484515bfff16d9 |
| institution | Directory Open Access Journal |
| issn | 2304-6732 |
| language | English |
| last_indexed | 2024-03-10T06:16:09Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Photonics |
| spelling | doaj.art-4ab16b09ba6449279f484515bfff16d92023-11-22T19:40:49ZengMDPI AGPhotonics2304-67322021-09-0181041410.3390/photonics8100414High Intensity Violet Light (405 nm) Inactivates Coronaviruses in Phosphate Buffered Saline (PBS) and on SurfacesBernhard Lau0Dietmar Becher1Martin Hessling2Institute of Medical Engineering and Mechatronics, Ulm University of Applied Sciences, 89075 Ulm, GermanyMICROMUN, Privates Institut für Mikrobiologische Forschung GmbH, 17489 Greifswald, GermanyInstitute of Medical Engineering and Mechatronics, Ulm University of Applied Sciences, 89075 Ulm, GermanyIt has been proven that visible light with a wavelength of about 405 nm exhibits an antimicrobial effect on bacteria and fungi if the irradiation doses are high enough. Hence, the question arises as to whether this violet light would also be suitable to inactivate SARS-CoV-2 coronaviruses. Therefore, a high-intensity light source was developed and applied to irradiate bovine coronaviruses (BCoV), which are employed as SARS-CoV-2 surrogates for safety reasons. Irradiation is performed in virus solutions diluted with phosphate buffered saline and on steel surfaces. Significant virus reduction by several log levels was observed both in the liquid and on the surface within half an hour with average log reduction doses of 57.5 and 96 J/cm<sup>2</sup>, respectively. Therefore, it can be concluded that 405 nm irradiation has an antiviral effect on coronaviruses, but special attention should be paid to the presence of photosensitizers in the virus environment in future experiments. Technically, visible violet radiation is therefore suitable for coronavirus reduction, but the required radiation doses are difficult to achieve rapidly.https://www.mdpi.com/2304-6732/8/10/414coronavirus disease 2019 (COVID-2019)bovine coronavirus (BCoV)severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)surrogatephotoinactivationphotosensitizer |
| spellingShingle | Bernhard Lau Dietmar Becher Martin Hessling High Intensity Violet Light (405 nm) Inactivates Coronaviruses in Phosphate Buffered Saline (PBS) and on Surfaces Photonics coronavirus disease 2019 (COVID-2019) bovine coronavirus (BCoV) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surrogate photoinactivation photosensitizer |
| title | High Intensity Violet Light (405 nm) Inactivates Coronaviruses in Phosphate Buffered Saline (PBS) and on Surfaces |
| title_full | High Intensity Violet Light (405 nm) Inactivates Coronaviruses in Phosphate Buffered Saline (PBS) and on Surfaces |
| title_fullStr | High Intensity Violet Light (405 nm) Inactivates Coronaviruses in Phosphate Buffered Saline (PBS) and on Surfaces |
| title_full_unstemmed | High Intensity Violet Light (405 nm) Inactivates Coronaviruses in Phosphate Buffered Saline (PBS) and on Surfaces |
| title_short | High Intensity Violet Light (405 nm) Inactivates Coronaviruses in Phosphate Buffered Saline (PBS) and on Surfaces |
| title_sort | high intensity violet light 405 nm inactivates coronaviruses in phosphate buffered saline pbs and on surfaces |
| topic | coronavirus disease 2019 (COVID-2019) bovine coronavirus (BCoV) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surrogate photoinactivation photosensitizer |
| url | https://www.mdpi.com/2304-6732/8/10/414 |
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