Clinical impact of p16 positivity in nasopharyngeal carcinoma
Abstract Purpose The clinical characteristics and prognosis of HPV‐related nasopharyngeal cancer (NPC) remain controversial. The relationship between p16 status and outcome was retrospectively investigated in the NPC patients. Materials and Methods Between May 2009 and May 2019, 81 NPC patients who...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-08-01
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| Series: | Laryngoscope Investigative Otolaryngology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/lio2.832 |
| _version_ | 1828758682972717056 |
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| author | Yuri Shimizu Naoya Murakami Taisuke Mori Kana Takahashi Yuko Kubo Seiichi Yoshimoto Yoshitaka Honma Satoshi Nakamura Hiroyuki Okamoto Kotaro Iijima Ayaka Takahashi Tomoya Kaneda Tairo Kashihara Koji Inaba Kae Okuma Yuko Nakayama Hiroshi Igaki Jun Itami |
| author_facet | Yuri Shimizu Naoya Murakami Taisuke Mori Kana Takahashi Yuko Kubo Seiichi Yoshimoto Yoshitaka Honma Satoshi Nakamura Hiroyuki Okamoto Kotaro Iijima Ayaka Takahashi Tomoya Kaneda Tairo Kashihara Koji Inaba Kae Okuma Yuko Nakayama Hiroshi Igaki Jun Itami |
| author_sort | Yuri Shimizu |
| collection | DOAJ |
| description | Abstract Purpose The clinical characteristics and prognosis of HPV‐related nasopharyngeal cancer (NPC) remain controversial. The relationship between p16 status and outcome was retrospectively investigated in the NPC patients. Materials and Methods Between May 2009 and May 2019, 81 NPC patients who received definitive radiation therapy, in a hospital in Japan, were identified and the prognosis was investigated. p16, p53, and Epstein–Barr virus (EBV) status were assessed. Also, circumferential tumor extent in the nasopharyngeal cavity was assessed on a 5‐point scale. Results Nine and 72 patients were p16‐positive and p16‐negative, respectively. Fewer patients were EBV‐encoded RNA in situ hybridization (EBER‐ISH)‐positive in the p16‐positive group than in the p16‐negative group (p < .01). Seventy‐five patients were nonkeratinizing NPCs, and six patients were keratinizing NPCs. There were two p16‐positive patients among the keratinizing NPCs. The mean circumferential tumor extent scores of 16‐positive and p16‐negative NPCs were 4.2 and 3.2, respectively with a statistically significant difference (p = .02). Two‐year progression‐free survival (PFS) of p16‐positive and p16‐negative patients undergoing chemoradiation therapy were 100% and 69%, respectively (p = .13). Conclusion In this study conducted in Japan, p16‐positive NPC patients are minor but not very low, and the proportion of keratinizing NPCs was small. p16‐positive NPCs were seen both in keratinizing and nonkeratinizing NPCs. P16‐positive NPC had a tendency of better PFS than p16‐negative NPC. This better prognosis might be due to the higher radiosensitivity of the p16‐positive cell. Additionally, p16‐positive NPCs seemed to spread more extensively in circumference along the nasopharyngeal mucosa than p16‐negative NPCs. |
| first_indexed | 2024-12-11T00:45:34Z |
| format | Article |
| id | doaj.art-4ab18304061e4d219e3b7363814f12fb |
| institution | Directory Open Access Journal |
| issn | 2378-8038 |
| language | English |
| last_indexed | 2024-12-11T00:45:34Z |
| publishDate | 2022-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj.art-4ab18304061e4d219e3b7363814f12fb2022-12-22T01:26:47ZengWileyLaryngoscope Investigative Otolaryngology2378-80382022-08-0174994100110.1002/lio2.832Clinical impact of p16 positivity in nasopharyngeal carcinomaYuri Shimizu0Naoya Murakami1Taisuke Mori2Kana Takahashi3Yuko Kubo4Seiichi Yoshimoto5Yoshitaka Honma6Satoshi Nakamura7Hiroyuki Okamoto8Kotaro Iijima9Ayaka Takahashi10Tomoya Kaneda11Tairo Kashihara12Koji Inaba13Kae Okuma14Yuko Nakayama15Hiroshi Igaki16Jun Itami17Department of Radiation Oncology National Cancer Center Hospital Tokyo JapanDepartment of Radiation Oncology National Cancer Center Hospital Tokyo JapanDepartment of Diagnostic Pathology National Cancer Center Hospital Tokyo JapanDepartment of Radiation Oncology National Cancer Center Hospital Tokyo JapanDepartment of Diagnostic Radiology National Cancer Center Hospital Tokyo JapanDepartment of Head and Neck Surgery National Cancer Center Hospital Tokyo JapanDepartment of Head and Neck, Esophageal Medical Oncology National Cancer Center Hospital Tokyo JapanRadiation Safety and Quality Assurance Division National Cancer Center Hospital Tokyo JapanRadiation Safety and Quality Assurance Division National Cancer Center Hospital Tokyo JapanRadiation Safety and Quality Assurance Division National Cancer Center Hospital Tokyo JapanDepartment of Radiation Oncology National Cancer Center Hospital Tokyo JapanDepartment of Radiation Oncology National Cancer Center Hospital Tokyo JapanDepartment of Radiation Oncology National Cancer Center Hospital Tokyo JapanDepartment of Radiation Oncology National Cancer Center Hospital Tokyo JapanDepartment of Radiation Oncology National Cancer Center Hospital Tokyo JapanDepartment of Radiation Oncology National Cancer Center Hospital Tokyo JapanDepartment of Radiation Oncology National Cancer Center Hospital Tokyo JapanDepartment of Radiation Oncology National Cancer Center Hospital Tokyo JapanAbstract Purpose The clinical characteristics and prognosis of HPV‐related nasopharyngeal cancer (NPC) remain controversial. The relationship between p16 status and outcome was retrospectively investigated in the NPC patients. Materials and Methods Between May 2009 and May 2019, 81 NPC patients who received definitive radiation therapy, in a hospital in Japan, were identified and the prognosis was investigated. p16, p53, and Epstein–Barr virus (EBV) status were assessed. Also, circumferential tumor extent in the nasopharyngeal cavity was assessed on a 5‐point scale. Results Nine and 72 patients were p16‐positive and p16‐negative, respectively. Fewer patients were EBV‐encoded RNA in situ hybridization (EBER‐ISH)‐positive in the p16‐positive group than in the p16‐negative group (p < .01). Seventy‐five patients were nonkeratinizing NPCs, and six patients were keratinizing NPCs. There were two p16‐positive patients among the keratinizing NPCs. The mean circumferential tumor extent scores of 16‐positive and p16‐negative NPCs were 4.2 and 3.2, respectively with a statistically significant difference (p = .02). Two‐year progression‐free survival (PFS) of p16‐positive and p16‐negative patients undergoing chemoradiation therapy were 100% and 69%, respectively (p = .13). Conclusion In this study conducted in Japan, p16‐positive NPC patients are minor but not very low, and the proportion of keratinizing NPCs was small. p16‐positive NPCs were seen both in keratinizing and nonkeratinizing NPCs. P16‐positive NPC had a tendency of better PFS than p16‐negative NPC. This better prognosis might be due to the higher radiosensitivity of the p16‐positive cell. Additionally, p16‐positive NPCs seemed to spread more extensively in circumference along the nasopharyngeal mucosa than p16‐negative NPCs.https://doi.org/10.1002/lio2.832head and neckHPVnasopharyngeal cancerp16radiation therapy |
| spellingShingle | Yuri Shimizu Naoya Murakami Taisuke Mori Kana Takahashi Yuko Kubo Seiichi Yoshimoto Yoshitaka Honma Satoshi Nakamura Hiroyuki Okamoto Kotaro Iijima Ayaka Takahashi Tomoya Kaneda Tairo Kashihara Koji Inaba Kae Okuma Yuko Nakayama Hiroshi Igaki Jun Itami Clinical impact of p16 positivity in nasopharyngeal carcinoma Laryngoscope Investigative Otolaryngology head and neck HPV nasopharyngeal cancer p16 radiation therapy |
| title | Clinical impact of p16 positivity in nasopharyngeal carcinoma |
| title_full | Clinical impact of p16 positivity in nasopharyngeal carcinoma |
| title_fullStr | Clinical impact of p16 positivity in nasopharyngeal carcinoma |
| title_full_unstemmed | Clinical impact of p16 positivity in nasopharyngeal carcinoma |
| title_short | Clinical impact of p16 positivity in nasopharyngeal carcinoma |
| title_sort | clinical impact of p16 positivity in nasopharyngeal carcinoma |
| topic | head and neck HPV nasopharyngeal cancer p16 radiation therapy |
| url | https://doi.org/10.1002/lio2.832 |
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