CXCL7 enhances RANKL-induced osteoclastogenesis via the activation of ERK/NFATc1 signaling pathway in inflammatory arthritis

CXCL7 enhances RANKL-induced osteoclastogenesis via the activation of ERK/NFATc1 signaling pathway in inflammatory arthritis

Abstract Background Rheumatoid arthritis (RA) with anti-citrullinated protein/peptide antibodies (ACPA + RA) demonstrates more significant radiographic damage compared to ACPA-negative RA (ACPA- RA). Chemokine-activated signaling pathways contribute to the regulation of the bone formation and resorp...

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Bibliographic Details
Main Authors: Xinyu Wang, Lin Sun, Zhuo An, Changhong Li, Jinxia Zhao
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Arthritis Research & Therapy
Subjects:
CXCL7
Osteoclast
Rheumatoid arthritis
RANKL
Collagen-induced arthritis
Online Access:https://doi.org/10.1186/s13075-025-03502-1

Internet

https://doi.org/10.1186/s13075-025-03502-1

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