Pharmaceutical Salts of Enrofloxacin with Organic Acids
Enrofloxacin is a poorly soluble antibacterial drug of the fluoroquinolones class used in veterinary medicine. The main purpose of this work was to investigate the structural and pharmaceutical properties of new enrofloxacin salts. Enrofloxacin anhydrate and its organic salts with tartaric acid, nic...
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MDPI AG
2020-07-01
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| Series: | Crystals |
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| Online Access: | https://www.mdpi.com/2073-4352/10/8/646 |
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| author | Hong Pang Yu-Bin Sun Jun-Wen Zhou Meng-Juan Xie Hao Lin Yan Yong Liang-Zhu Chen Bing-Hu Fang |
| author_facet | Hong Pang Yu-Bin Sun Jun-Wen Zhou Meng-Juan Xie Hao Lin Yan Yong Liang-Zhu Chen Bing-Hu Fang |
| author_sort | Hong Pang |
| collection | DOAJ |
| description | Enrofloxacin is a poorly soluble antibacterial drug of the fluoroquinolones class used in veterinary medicine. The main purpose of this work was to investigate the structural and pharmaceutical properties of new enrofloxacin salts. Enrofloxacin anhydrate and its organic salts with tartaric acid, nicotinic acid and suberic acid formed as pure crystalline anhydrous solids. All the crystals were grown from a mixed solution by slow evaporation at room temperature. These products were then characterized by field-emission scanning electron microscopy, powder X-ray diffraction, Fourier transform infrared spectroscopy and differential scanning calorimetry. Further, X-ray single crystal diffraction analysis was used to study the crystal structure. The intermolecular interactions and packing arrangements in the crystal structures were studied, and the solubility of these salts in water was determined using high-performance liquid chromatography. The results show that the new salts of enrofloxacin developed in this study exhibited excellent water solubility. |
| first_indexed | 2024-03-10T18:11:00Z |
| format | Article |
| id | doaj.art-4ab391a0c7c248b6bd2ec0c0ca394d73 |
| institution | Directory Open Access Journal |
| issn | 2073-4352 |
| language | English |
| last_indexed | 2024-03-10T18:11:00Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Crystals |
| spelling | doaj.art-4ab391a0c7c248b6bd2ec0c0ca394d732023-11-20T08:04:32ZengMDPI AGCrystals2073-43522020-07-0110864610.3390/cryst10080646Pharmaceutical Salts of Enrofloxacin with Organic AcidsHong Pang0Yu-Bin Sun1Jun-Wen Zhou2Meng-Juan Xie3Hao Lin4Yan Yong5Liang-Zhu Chen6Bing-Hu Fang7National Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, South China Agricultural University, Guangzhou 510000, ChinaNational Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, South China Agricultural University, Guangzhou 510000, ChinaNational Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, South China Agricultural University, Guangzhou 510000, ChinaNational Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, South China Agricultural University, Guangzhou 510000, ChinaNational Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, South China Agricultural University, Guangzhou 510000, ChinaGuangdong Dahuanong Animal Health Products Co. Ltd., Yunfu 527400, ChinaGuangdong Dahuanong Animal Health Products Co. Ltd., Yunfu 527400, ChinaNational Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, South China Agricultural University, Guangzhou 510000, ChinaEnrofloxacin is a poorly soluble antibacterial drug of the fluoroquinolones class used in veterinary medicine. The main purpose of this work was to investigate the structural and pharmaceutical properties of new enrofloxacin salts. Enrofloxacin anhydrate and its organic salts with tartaric acid, nicotinic acid and suberic acid formed as pure crystalline anhydrous solids. All the crystals were grown from a mixed solution by slow evaporation at room temperature. These products were then characterized by field-emission scanning electron microscopy, powder X-ray diffraction, Fourier transform infrared spectroscopy and differential scanning calorimetry. Further, X-ray single crystal diffraction analysis was used to study the crystal structure. The intermolecular interactions and packing arrangements in the crystal structures were studied, and the solubility of these salts in water was determined using high-performance liquid chromatography. The results show that the new salts of enrofloxacin developed in this study exhibited excellent water solubility.https://www.mdpi.com/2073-4352/10/8/646enrofloxacinsaltscrystal structureorganic acidssolubility |
| spellingShingle | Hong Pang Yu-Bin Sun Jun-Wen Zhou Meng-Juan Xie Hao Lin Yan Yong Liang-Zhu Chen Bing-Hu Fang Pharmaceutical Salts of Enrofloxacin with Organic Acids Crystals enrofloxacin salts crystal structure organic acids solubility |
| title | Pharmaceutical Salts of Enrofloxacin with Organic Acids |
| title_full | Pharmaceutical Salts of Enrofloxacin with Organic Acids |
| title_fullStr | Pharmaceutical Salts of Enrofloxacin with Organic Acids |
| title_full_unstemmed | Pharmaceutical Salts of Enrofloxacin with Organic Acids |
| title_short | Pharmaceutical Salts of Enrofloxacin with Organic Acids |
| title_sort | pharmaceutical salts of enrofloxacin with organic acids |
| topic | enrofloxacin salts crystal structure organic acids solubility |
| url | https://www.mdpi.com/2073-4352/10/8/646 |
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