Whole Genome Sequencing of Hepatitis A Virus Using a PCR-Free Single-Molecule Nanopore Sequencing Approach

Whole Genome Sequencing of Hepatitis A Virus Using a PCR-Free Single-Molecule Nanopore Sequencing Approach

Hepatitis A virus (HAV) is one of the most common causes of acute viral hepatitis in humans. Although HAV has a relatively small genome, there are several factors limiting whole genome sequencing such as PCR amplification artefacts and ambiguities in de novo assembly. The recently developed Oxford N...

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Bibliographic Details
Main Authors: Frederico M. Batista, Tina Stapleton, James A. Lowther, Vera G. Fonseca, Rebecca Shaw, Christopher Pond, David I. Walker, Ronny van Aerle, Jaime Martinez-Urtaza
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Microbiology
Subjects:
hepatitis A virus
Picornaviridae
genome
nanopore sequencing
metagenomics
SNV
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00874/full

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