The Prevalence of Inducible and Constitutive Clindamycin Resistance Among the Nasal Isolates of Staphylococci
Context: One of the important sources of Staphylococci which causes nosocomial infections, is the nasal carriage of Staphylococci among Health Care Workers (HCWs). The commonest antibiotic which is preferred for the treatment of the methicillin and multi drug resistant Staphylococcal infections...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/3223/25-%206378_E(C)_PF1(M)_F(P)_PF1(P)_PF1(PPR)_PFA(PR)_PF3_(PUH)_B.pdf |
| Summary: | Context: One of the important sources of Staphylococci
which causes nosocomial infections, is the nasal carriage
of Staphylococci among Health Care Workers (HCWs). The
commonest antibiotic which is preferred for the treatment
of the methicillin and multi drug resistant Staphylococcal
infections is clindamycin. The inducible clindamycin resistance
in Staphylococci is not detected by the routine antibiotic
susceptibility testing and it results in treatment failures.
Aim: The present study was undertaken to know the prevalence
of constitutive and inducible clindamycin resistance and its
correlation with the methicillin resistance among the nasal
isolates of Staphylococci which were obtained from different
HCWs.
Material and Methods: Nasal swabs were collected from 206
HCWs and they were processed. The Staphylococci which were
isolated were tested for methicillin resistance by using cefoxitin
(30 µg) discs. The inducible clindamycin resistance was tested
by using erythromycin (15 µg) and clindamycin (2µg) discs and
the D test according to the CLSI guidelines.
Results: Inducible clindamycin resistance was seen in
21(16.40%) of the S.aureus and 14 (7.56%) of the coagulase
negative Staphylococcal isolates. Constitutive clindamycin
resistance was seen in 23(17.96%) of the S.aureus and
43(23.24%) of the coagulase negative Staphylococcal isolates.
The inducible and constitutive clindamycin resistance was
more common among the methicillin resistant Staphylococcal
isolates.
Conclusion: The prevalence of inducible and constitutive
clindamycin resistance in the nasal Staphylococcal isolates
which were obtained from the HCWs was high, especially
among the methicillin resistant Staphylococci. The D test which
is recommended by the CLSI should be routinely done to detect
inducible clindamycin resistance, to prevent treatment failures. |
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| ISSN: | 2249-782X 0973-709X |