On the material dependency of peri-implant morphology and stability in healing bone
The microstructural architecture of remodeled bone in the peri-implant region of screw implants plays a vital role in the distribution of strain energy and implant stability. We present a study in which screw implants made from titanium, polyetheretherketone and biodegradable magnesium-gadolinium al...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-10-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X23001500 |
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| author | Stefan Bruns Diana Krüger Silvia Galli D.C. Florian Wieland Jörg U. Hammel Felix Beckmann Ann Wennerberg Regine Willumeit-Römer Berit Zeller-Plumhoff Julian Moosmann |
| author_facet | Stefan Bruns Diana Krüger Silvia Galli D.C. Florian Wieland Jörg U. Hammel Felix Beckmann Ann Wennerberg Regine Willumeit-Römer Berit Zeller-Plumhoff Julian Moosmann |
| author_sort | Stefan Bruns |
| collection | DOAJ |
| description | The microstructural architecture of remodeled bone in the peri-implant region of screw implants plays a vital role in the distribution of strain energy and implant stability. We present a study in which screw implants made from titanium, polyetheretherketone and biodegradable magnesium-gadolinium alloys were implanted into rat tibia and subjected to a push-out test four, eight and twelve weeks after implantation. Screws were 4 mm in length and with an M2 thread. The loading experiment was accompanied by simultaneous three-dimensional imaging using synchrotron-radiation microcomputed tomography at 5 μm resolution. Bone deformation and strains were tracked by applying optical flow-based digital volume correlation to the recorded image sequences. Implant stabilities measured for screws of biodegradable alloys were comparable to pins whereas non-degradable biomaterials experienced additional mechanical stabilization. Peri-implant bone morphology and strain transfer from the loaded implant site depended heavily on the biomaterial utilized. Titanium implants stimulated rapid callus formation displaying a consistent monomodal strain profile whereas the bone volume fraction in the vicinity of magnesium-gadolinium alloys exhibited a minimum close to the interface of the implant and less ordered strain transfer. Correlations in our data suggest that implant stability benefits from disparate bone morphological properties depending on the biomaterial utilized. This leaves the choice of biomaterial as situational depending on local tissue properties. |
| first_indexed | 2024-03-12T22:02:56Z |
| format | Article |
| id | doaj.art-4ab9adb0bd4247a4b7deaef2bb6a62c8 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2025-03-22T04:40:23Z |
| publishDate | 2023-10-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-4ab9adb0bd4247a4b7deaef2bb6a62c82024-04-27T22:33:29ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-10-0128155166On the material dependency of peri-implant morphology and stability in healing boneStefan Bruns0Diana Krüger1Silvia Galli2D.C. Florian Wieland3Jörg U. Hammel4Felix Beckmann5Ann Wennerberg6Regine Willumeit-Römer7Berit Zeller-Plumhoff8Julian Moosmann9Institute of Metallic Biomaterials, Helmholtz-Zentrum Hereon, Max-Planck-Str. 1, 21502, Geesthacht, Germany; Corresponding author.Institute of Metallic Biomaterials, Helmholtz-Zentrum Hereon, Max-Planck-Str. 1, 21502, Geesthacht, GermanyUniversity of Malmö, Faculty of Odontology, Department of Prosthodontics, Carl Gustafs Väg 34, Klerken, 20506, Malmö, SwedenInstitute of Metallic Biomaterials, Helmholtz-Zentrum Hereon, Max-Planck-Str. 1, 21502, Geesthacht, GermanyInstitute of Materials Physics, Helmholtz-Zentrum Hereon, Max-Planck-Str. 1, 21502, Geesthacht, GermanyInstitute of Materials Physics, Helmholtz-Zentrum Hereon, Max-Planck-Str. 1, 21502, Geesthacht, GermanyUniversity of Gothenburg, Institute of Odontology, Department of Prosthodontics, Medicinaregatan 12 f, 41390, Göteborg, SwedenInstitute of Metallic Biomaterials, Helmholtz-Zentrum Hereon, Max-Planck-Str. 1, 21502, Geesthacht, GermanyInstitute of Metallic Biomaterials, Helmholtz-Zentrum Hereon, Max-Planck-Str. 1, 21502, Geesthacht, Germany; Corresponding author.Institute of Materials Physics, Helmholtz-Zentrum Hereon, Max-Planck-Str. 1, 21502, Geesthacht, GermanyThe microstructural architecture of remodeled bone in the peri-implant region of screw implants plays a vital role in the distribution of strain energy and implant stability. We present a study in which screw implants made from titanium, polyetheretherketone and biodegradable magnesium-gadolinium alloys were implanted into rat tibia and subjected to a push-out test four, eight and twelve weeks after implantation. Screws were 4 mm in length and with an M2 thread. The loading experiment was accompanied by simultaneous three-dimensional imaging using synchrotron-radiation microcomputed tomography at 5 μm resolution. Bone deformation and strains were tracked by applying optical flow-based digital volume correlation to the recorded image sequences. Implant stabilities measured for screws of biodegradable alloys were comparable to pins whereas non-degradable biomaterials experienced additional mechanical stabilization. Peri-implant bone morphology and strain transfer from the loaded implant site depended heavily on the biomaterial utilized. Titanium implants stimulated rapid callus formation displaying a consistent monomodal strain profile whereas the bone volume fraction in the vicinity of magnesium-gadolinium alloys exhibited a minimum close to the interface of the implant and less ordered strain transfer. Correlations in our data suggest that implant stability benefits from disparate bone morphological properties depending on the biomaterial utilized. This leaves the choice of biomaterial as situational depending on local tissue properties.http://www.sciencedirect.com/science/article/pii/S2452199X23001500Biodegradable implant materialsBone mechanical testingImplant stabilitySynchrotron micro-computed tomography imagingDigital volume correlation |
| spellingShingle | Stefan Bruns Diana Krüger Silvia Galli D.C. Florian Wieland Jörg U. Hammel Felix Beckmann Ann Wennerberg Regine Willumeit-Römer Berit Zeller-Plumhoff Julian Moosmann On the material dependency of peri-implant morphology and stability in healing bone Bioactive Materials Biodegradable implant materials Bone mechanical testing Implant stability Synchrotron micro-computed tomography imaging Digital volume correlation |
| title | On the material dependency of peri-implant morphology and stability in healing bone |
| title_full | On the material dependency of peri-implant morphology and stability in healing bone |
| title_fullStr | On the material dependency of peri-implant morphology and stability in healing bone |
| title_full_unstemmed | On the material dependency of peri-implant morphology and stability in healing bone |
| title_short | On the material dependency of peri-implant morphology and stability in healing bone |
| title_sort | on the material dependency of peri implant morphology and stability in healing bone |
| topic | Biodegradable implant materials Bone mechanical testing Implant stability Synchrotron micro-computed tomography imaging Digital volume correlation |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X23001500 |
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