Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro
A novel accessory directing the blood from the outflow of a left ventricular assist device (LVAD) back through the left ventricular apex and across the aortic valve allows LVAD implantation via the left ventricular apex solely but may affect the LVAD performance. We quantified the effect of the acce...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/10/4/486 |
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| author | Florian Meissner Derya Eichelkraut Marius Schimmel Sven Maier Heiko Vestner Manuela Schoen Martin Czerny Wolfgang Bothe |
| author_facet | Florian Meissner Derya Eichelkraut Marius Schimmel Sven Maier Heiko Vestner Manuela Schoen Martin Czerny Wolfgang Bothe |
| author_sort | Florian Meissner |
| collection | DOAJ |
| description | A novel accessory directing the blood from the outflow of a left ventricular assist device (LVAD) back through the left ventricular apex and across the aortic valve allows LVAD implantation via the left ventricular apex solely but may affect the LVAD performance. We quantified the effect of the accessory on LVAD flow and pressure head in vitro. In a mock circulatory loop, a centrifugal-flow LVAD (HeartMate 3, Abbott, Abbott Park, IL, USA) with (Accessory) and without the accessory (Control) was compared under physiological conditions using a water/glycerol solution as a blood substitute. The pump was operated at 4000, 5200, and 6400 rpm and 5 different resistance levels. Flow, inlet, and outlet pressure were measured, and pressure head was calculated. Compared to the Control, flow and pressure head in the Accessory group were reduced by an overall average of 0.26 L/min and 9.9 mmHg (all speeds and resistance levels). The highest decline in flow and pressure head occurred at the lowest resistance levels. In conclusion, the accessory leads to a reduction of LVAD flow and pressure head that is enhanced by decreases in resistance. Future developments in the LVAD accessory’s design may reduce these effects and allow unimpaired LVAD performance and minimally invasive device implantation. |
| first_indexed | 2024-03-11T05:13:52Z |
| format | Article |
| id | doaj.art-4ab9dde0c5494b42a6867193fa3edbd1 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-11T05:13:52Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-4ab9dde0c5494b42a6867193fa3edbd12023-11-17T18:22:46ZengMDPI AGBioengineering2306-53542023-04-0110448610.3390/bioengineering10040486Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In VitroFlorian Meissner0Derya Eichelkraut1Marius Schimmel2Sven Maier3Heiko Vestner4Manuela Schoen5Martin Czerny6Wolfgang Bothe7Department of Cardiovascular Surgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, GermanyDepartment of Cardiovascular Surgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, GermanyDepartment of Cardiovascular Surgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, GermanyDepartment of Cardiovascular Surgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, GermanyDepartment of Cardiovascular Surgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, GermanyDepartment of Cardiovascular Surgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, GermanyDepartment of Cardiovascular Surgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, GermanyDepartment of Cardiovascular Surgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, GermanyA novel accessory directing the blood from the outflow of a left ventricular assist device (LVAD) back through the left ventricular apex and across the aortic valve allows LVAD implantation via the left ventricular apex solely but may affect the LVAD performance. We quantified the effect of the accessory on LVAD flow and pressure head in vitro. In a mock circulatory loop, a centrifugal-flow LVAD (HeartMate 3, Abbott, Abbott Park, IL, USA) with (Accessory) and without the accessory (Control) was compared under physiological conditions using a water/glycerol solution as a blood substitute. The pump was operated at 4000, 5200, and 6400 rpm and 5 different resistance levels. Flow, inlet, and outlet pressure were measured, and pressure head was calculated. Compared to the Control, flow and pressure head in the Accessory group were reduced by an overall average of 0.26 L/min and 9.9 mmHg (all speeds and resistance levels). The highest decline in flow and pressure head occurred at the lowest resistance levels. In conclusion, the accessory leads to a reduction of LVAD flow and pressure head that is enhanced by decreases in resistance. Future developments in the LVAD accessory’s design may reduce these effects and allow unimpaired LVAD performance and minimally invasive device implantation.https://www.mdpi.com/2306-5354/10/4/486left ventricular assist deviceheart failuremock circulatory loopin vitro |
| spellingShingle | Florian Meissner Derya Eichelkraut Marius Schimmel Sven Maier Heiko Vestner Manuela Schoen Martin Czerny Wolfgang Bothe Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro Bioengineering left ventricular assist device heart failure mock circulatory loop in vitro |
| title | Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro |
| title_full | Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro |
| title_fullStr | Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro |
| title_full_unstemmed | Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro |
| title_short | Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro |
| title_sort | impact of an accessory for left ventricular assist devices on device flow and pressure head in vitro |
| topic | left ventricular assist device heart failure mock circulatory loop in vitro |
| url | https://www.mdpi.com/2306-5354/10/4/486 |
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