G Protein-Coupled Estrogen Receptor Protects From Angiotensin II-Induced Increases in Pulse Pressure and Oxidative Stress

G Protein-Coupled Estrogen Receptor Protects From Angiotensin II-Induced Increases in Pulse Pressure and Oxidative Stress

Our previous work showed that the G protein-coupled estrogen receptor (GPER) is protective in the vasculature and kidneys during angiotensin (Ang) II-dependent hypertension by inhibiting oxidative stress. The goal of the current study was to assess the impact of GPER deletion on sex differences in A...

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Bibliographic Details
Main Authors: Benard O. Ogola, Margaret A. Zimmerman, Venkata N. Sure, Kaylee M. Gentry, Jennifer L. Duong, Gabrielle L. Clark, Kristin S. Miller, Prasad V. G. Katakam, Sarah H. Lindsey
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Endocrinology
Subjects:
estrogen
G protein-coupled estrogen receptor
NADPH oxidase 4
oxidative stress
cell signaling/signal transduction
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00586/full

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