Poloxamer/Carboxymethyl Pullulan Aqueous Systems—Miscibility and Thermogelation Studies Using Viscometry, Rheology and Dynamic Light Scattering
Thermally-induced gelling systems based on Poloxamer 407 (PL) and polysaccharides are known for their biomedical applications; however, phase separation frequently occurs in mixtures of poloxamer and neutral polysaccharides. In the present paper, the carboxymethyl pullulan (CMP) (here synthesized) w...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/8/1909 |
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| author | Irina Popescu Marieta Constantin Maria Bercea Bogdan-Paul Coșman Dana Mihaela Suflet Gheorghe Fundueanu |
| author_facet | Irina Popescu Marieta Constantin Maria Bercea Bogdan-Paul Coșman Dana Mihaela Suflet Gheorghe Fundueanu |
| author_sort | Irina Popescu |
| collection | DOAJ |
| description | Thermally-induced gelling systems based on Poloxamer 407 (PL) and polysaccharides are known for their biomedical applications; however, phase separation frequently occurs in mixtures of poloxamer and neutral polysaccharides. In the present paper, the carboxymethyl pullulan (CMP) (here synthesized) was proposed for compatibilization with poloxamer (PL). The miscibility between PL and CMP in dilute aqueous solution was studied by capillary viscometry. CMP with substitution degrees higher than 0.5 proved to be compatible with PL. The thermogelation of concentrated PL solutions (17%) in the presence of CMP was monitored by the tube inversion method, texture analysis and rheology. The micellization and gelation of PL in the absence or in the presence of CMP were also studied by dynamic light scattering. The critical micelle temperature and sol–gel transition temperature decrease with the addition of CMP, but the concentration of CMP has a peculiar influence on the rheological parameters of the gels. In fact, low concentrations of CMP decrease the gel strength. With a further increase in polyelectrolyte concentration, the gel strength increases until 1% CMP, then the rheological parameters are lowered again. At 37 °C, the gels are able to recover the initial network structure after high deformations, showing a reversible healing process. |
| first_indexed | 2024-03-11T04:35:57Z |
| format | Article |
| id | doaj.art-4abad191c04e4132a5f41b5e125ef3e9 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-11T04:35:57Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-4abad191c04e4132a5f41b5e125ef3e92023-11-17T21:02:18ZengMDPI AGPolymers2073-43602023-04-01158190910.3390/polym15081909Poloxamer/Carboxymethyl Pullulan Aqueous Systems—Miscibility and Thermogelation Studies Using Viscometry, Rheology and Dynamic Light ScatteringIrina Popescu0Marieta Constantin1Maria Bercea2Bogdan-Paul Coșman3Dana Mihaela Suflet4Gheorghe Fundueanu5“Petru Poni” Institute of Macromolecular Chemistry, 41-A Grigore Ghica Voda Alley, 700487 Iasi, Romania“Petru Poni” Institute of Macromolecular Chemistry, 41-A Grigore Ghica Voda Alley, 700487 Iasi, Romania“Petru Poni” Institute of Macromolecular Chemistry, 41-A Grigore Ghica Voda Alley, 700487 Iasi, Romania“Petru Poni” Institute of Macromolecular Chemistry, 41-A Grigore Ghica Voda Alley, 700487 Iasi, Romania“Petru Poni” Institute of Macromolecular Chemistry, 41-A Grigore Ghica Voda Alley, 700487 Iasi, Romania“Petru Poni” Institute of Macromolecular Chemistry, 41-A Grigore Ghica Voda Alley, 700487 Iasi, RomaniaThermally-induced gelling systems based on Poloxamer 407 (PL) and polysaccharides are known for their biomedical applications; however, phase separation frequently occurs in mixtures of poloxamer and neutral polysaccharides. In the present paper, the carboxymethyl pullulan (CMP) (here synthesized) was proposed for compatibilization with poloxamer (PL). The miscibility between PL and CMP in dilute aqueous solution was studied by capillary viscometry. CMP with substitution degrees higher than 0.5 proved to be compatible with PL. The thermogelation of concentrated PL solutions (17%) in the presence of CMP was monitored by the tube inversion method, texture analysis and rheology. The micellization and gelation of PL in the absence or in the presence of CMP were also studied by dynamic light scattering. The critical micelle temperature and sol–gel transition temperature decrease with the addition of CMP, but the concentration of CMP has a peculiar influence on the rheological parameters of the gels. In fact, low concentrations of CMP decrease the gel strength. With a further increase in polyelectrolyte concentration, the gel strength increases until 1% CMP, then the rheological parameters are lowered again. At 37 °C, the gels are able to recover the initial network structure after high deformations, showing a reversible healing process.https://www.mdpi.com/2073-4360/15/8/1909Poloxamer 407carboxymethyl pullulancompatibilityviscoelastic propertiessol–gel transitiondynamic light scattering |
| spellingShingle | Irina Popescu Marieta Constantin Maria Bercea Bogdan-Paul Coșman Dana Mihaela Suflet Gheorghe Fundueanu Poloxamer/Carboxymethyl Pullulan Aqueous Systems—Miscibility and Thermogelation Studies Using Viscometry, Rheology and Dynamic Light Scattering Polymers Poloxamer 407 carboxymethyl pullulan compatibility viscoelastic properties sol–gel transition dynamic light scattering |
| title | Poloxamer/Carboxymethyl Pullulan Aqueous Systems—Miscibility and Thermogelation Studies Using Viscometry, Rheology and Dynamic Light Scattering |
| title_full | Poloxamer/Carboxymethyl Pullulan Aqueous Systems—Miscibility and Thermogelation Studies Using Viscometry, Rheology and Dynamic Light Scattering |
| title_fullStr | Poloxamer/Carboxymethyl Pullulan Aqueous Systems—Miscibility and Thermogelation Studies Using Viscometry, Rheology and Dynamic Light Scattering |
| title_full_unstemmed | Poloxamer/Carboxymethyl Pullulan Aqueous Systems—Miscibility and Thermogelation Studies Using Viscometry, Rheology and Dynamic Light Scattering |
| title_short | Poloxamer/Carboxymethyl Pullulan Aqueous Systems—Miscibility and Thermogelation Studies Using Viscometry, Rheology and Dynamic Light Scattering |
| title_sort | poloxamer carboxymethyl pullulan aqueous systems miscibility and thermogelation studies using viscometry rheology and dynamic light scattering |
| topic | Poloxamer 407 carboxymethyl pullulan compatibility viscoelastic properties sol–gel transition dynamic light scattering |
| url | https://www.mdpi.com/2073-4360/15/8/1909 |
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